Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice.
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Date
2015-05
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Abstract
Background: Operculina turpethum Linn. (Convolvulaceae) is commonly called
“Trivrit” or “India jalap” in English. It is a perennial herbaceous plant with purplish
stem and milky-white exudates. This study was aimed at evaluation of the analgesic
and antioxidant effects of the methanolic extract of O. turpethum leaves in mice.
Methods: The acute oral toxicity of the extract was evaluated using up and down
method. The analgesic effects were assessed using acetic acid-induced abdominal
writhing reflex and tail flick methods, while the antioxidant activity (AA) was
assayed using photometric 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging
assay method.
Results: The extract produced a concentration-dependent increase in the AA with
inhibitory concentration 50% >400 μg/ml. The extract (100, 200 and 400 mg/kg)
and aspirin (100 mg/kg) produced a significant (p<0.05) dose-dependent reduction in
the number of abdominal constriction induced by intraperitoneal injection of acetic
acid in treated mice when compared to the distilled water treated mice. The extract
(100, 200, and 400 mg/kg) and pentazocine (3 mg/kg) caused a significant (p<0.05)
dose-dependent increase in the pain reaction time in the treated mice groups, when
compared to the distilled water treated groups.
Conclusion: The study showed that O. turpethum possesses analgesic and antioxidant
properties and confirmed the folkloric use of O. turpethum leaves in the traditional
pain management.
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Keywords
Operculina turpethum, Analgesic, Antioxidant, Acetic acids, Pentazocine, Tail flick response
Citation
Ezeja Maxwell I, Onoja Samuel O, Omeh Yusuf N, Chibiko Chijioke A. Analgesic and antioxidant activities of the methanolic extract of Operculina turpethum leaves in mice. International Journal of Basic & Clinical Pharmacology. 2015 May-Jun; 4(3): 453-457.