Sub chronic toxicity studies of lactulose in rats.

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dc.contributor.authorBaskaran, Ven_US
dc.contributor.authorMurthy, K Nen_US
dc.contributor.authorMahadevamma,en_US
dc.contributor.authorVishwanatha, Sen_US
dc.contributor.authorLokesh, B Ren_US
dc.date.accessioned2009-05-28T13:24:49Z
dc.date.available2009-05-28T13:24:49Z
dc.date.issued2001-05-21en_US
dc.description.abstractLactulose has profound health benefits by way of increasing bifidobacterial flora in the intestine of infants thereby protecting them against enteric infection, constipation and systemic encephalopathy. In the present study to assess the sub chronic toxicity of lactulose syrup, the rats were fed on a basal feed supplemented with lactulose syrup at 0.5, 1.0, 2.0 and 5.0% for a period of 21 weeks. Monitoring of food consumption, gain in body weight and physical observations did not reveal any treatment-related toxicity in any of the group of rats. Terminal autopsy also did not reveal any signs of toxicity. Further, no significant alterations in relative organ weight, serum biochemistry and urinalysis were observed up to 1% lactulose supplementation level. The results suggest that supplementation of lactulose in the diet does not produce any toxicity at the doses tested.en_US
dc.description.affiliationDepartment of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570 013, India.en_US
dc.identifier.citationBaskaran V, Murthy KN, Mahadevamma , Vishwanatha S, Lokesh BR. Sub chronic toxicity studies of lactulose in rats. Indian Journal of Experimental Biology. 2001 May; 39(5): 441-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59376
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Cell Counten_US
dc.subject.meshBlood Chemical Analysisen_US
dc.subject.meshDietary Supplements --toxicityen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshLactulose --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshOrgan Size --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSafetyen_US
dc.subject.meshWeight Gain --drug effectsen_US
dc.titleSub chronic toxicity studies of lactulose in rats.en_US
dc.typeJournal Articleen_US
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