Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients
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Date
2025-03
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer - Medknow
Abstract
Epstein?Barr virus (EBV) is a lymphotropic virus that causes diseases ranging from a flu?like illness called infectious mononucleosis to nasopharyngeal carcinoma, Burkitt’s lymphoma, and central nervous system (CNS) infection. Detection of EBV DNA is usually done using whole blood samples taken from the patients. We undertook the detection of EBV in blood, cerebrospinal fluid (CSF), and saliva by real?time quantitative PCR in two patients, one with a history of nasopharyngeal carcinoma, and the other having a case of viral encephalitis. EBV was detected only in saliva, whole blood in both patients, and CSF in the second case tested negative. This case series illustrates the importance of testing for EBV DNAemia in saliva by real?time polymerase chain reaction (PCR) to rule in a diagnosis of EBV.
Description
Keywords
Clinical awareness, Epstein?Barr virus, real?time quantitative PCR, saliva
Citation
Srinivasan N, Barani R, Manickavasagan M, Srikanth P. Epstein-Barr virus (EBV) DNAemia in saliva of viral encephalitis and nasopharyngeal carcinoma patients. Indian Journal of Pathology & Microbiology. 2025 Mar; 68(1): 208-211