Short-term Effects of Garlic-Based Diets on mRNA Expression of Angiotensinogen, Angiotensin-1 Converting Enzyme, and Atrial Natriuretic Peptide in Cyclosporine-Induced Prehypertensive Rats

Simple item page
dc.contributor.authorAjayi, O. O.en_US
dc.contributor.authorAjayi, O. B.en_US
dc.date.accessioned2023-07-14T08:03:57Z
dc.date.available2023-07-14T08:03:57Z
dc.date.issued2023-05
dc.description.abstractThe short-term effects of garlic, Allium sativum L., on the mRNA expression of angiotensin-1 converting enzyme (ACE), angiotensinogen (AGT), and atrial natriuretic peptide (ANP) in cyclosporine-induced prehypertensive rats were investigated in this work. Seven (7) groups of animals totaling n=7 were created. Prehypertensive (induced with 25mg/kg cyclosporine) and normal rats were given 10% and 20% diets based on garlic for 7 days. Alteration of Na+ and K+ levels, increased systolic and diastolic blood pressures, and ACE, AGT & ANP mRNA expressions were all associated with cyclosporin-induced prehypertension. In rats placed on garlic-based diets, these effects were reversed.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Faculty of Science, Ekiti-State University, Ado-Ekiti, Ekiti-State, Nigeriaen_US
dc.identifier.citationAjayi O. O., Ajayi O. B.. Short-term Effects of Garlic-Based Diets on mRNA Expression of Angiotensinogen, Angiotensin-1 Converting Enzyme, and Atrial Natriuretic Peptide in Cyclosporine-Induced Prehypertensive Rats. Annual Research & Review in Biology. 2023 May; 38(5): 32-42en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219413
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber5en_US
dc.relation.volume38en_US
dc.source.urihttps://doi.org/10.9734/arrb/2023/v38i530586en_US
dc.subjectHypertensionen_US
dc.subjectcyclosporineen_US
dc.subjectgarlicen_US
dc.subjectrenin-angiotensin system.en_US
dc.titleShort-term Effects of Garlic-Based Diets on mRNA Expression of Angiotensinogen, Angiotensin-1 Converting Enzyme, and Atrial Natriuretic Peptide in Cyclosporine-Induced Prehypertensive Ratsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ARRB2023v38n5p32.pdf
Size:
733.23 KB
Format:
Adobe Portable Document Format
Download
Collections
Annual Research & Review in Biology