Formulation and in vitro Characterization of Donepezil-loaded Chitosan Nanoparticles

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dc.contributor.authorAmjad, Muhammad Wahaben_US
dc.contributor.authorAlotaibi, Nawaf Mohameden_US
dc.date.accessioned2020-11-18T10:30:10Z
dc.date.available2020-11-18T10:30:10Z
dc.date.issued2020-06
dc.description.abstractMillions of people are affected globally by alzheimer’sdisease and it is regarded as a dangerous progressive medical and socio-economic burden. The drug delivery to brain is hindered due to the presence of blood brain barrier. Nanoparticle mediated drug delivery is a promising approach in this regard. Chitosan is a hydrophilic polysaccharide polymer of N-acetylglycosamine and glucosamine. Owing to its biodegradability, nontoxicity and biocompatibility it is regarded as a safe excipient. The aim of the study was to fabricate donepezil-loaded sustained release chitosan nanoparticles as a simple way to deliver nano-drugs to the brain. The nanoparticles were fabricated using ionic gelation method using different concentrations of Sodium tripolyphosphate (TPP) and chitosan. The fabricated nanoparticles were assessedfor particle size, zeta potential, encapsulation efficiency and in vitrodrug release. The effect of sonication time on the particle size of nanoparticles was also studied. The nanoparticles exhibited mean particle size (between 135-1487nm) and zeta potential (between +3.9-+38mV) depending on chitosan and TPP concentration used. The rise in the sonication time from 25 to 125 sec exhibited a decrease in particle size. The encapsulation efficiency was found to be in the range of 39.1-74.4%. Sustained and slow release of donepezil at a constant rate was exhibited from nanoparticles. The nanoparticles show potential to deliver donepezil to brain with enhanced encapsulation efficiencyen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Faculty of Pharmacy, Northern Border University, Rafha, Saudi Arabia.en_US
dc.identifier.citationAmjad Muhammad Wahab, Alotaibi Nawaf Mohamed. Formulation and in vitro Characterization of Donepezil-loaded Chitosan Nanoparticles. Journal of Pharmaceutical Research International. 2020 Jun; 32(10): 10-16en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215776
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber10en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i1030488en_US
dc.subjectChitosanen_US
dc.subjectdonepezilen_US
dc.subjectnanoparticlesen_US
dc.subjectencapsulation efficiencyen_US
dc.subjectdrug releaseen_US
dc.titleFormulation and in vitro Characterization of Donepezil-loaded Chitosan Nanoparticlesen_US
dc.typeJournal Articleen_US
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