Lamotrigine-induced fulminant hepatic failure: an unusual presentation.
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Date
2015-03
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Abstract
Lamotrigine (LTG) is indicated for the management of seizures either alone or in
combination with other anticonvulsant agents. Adverse effects with it are usually
mild. Less than 1% of subjects show deranged liver function tests during long therapy.
Fulminant hepatic failure with LTG is an unusual presentation. We report a fatal case
of hepatic failure with LTG monotherapy in a 22-year-old male patient suffering
from a seizure disorder. Cases of LTG induced hepatotoxicity should be carefully
monitored, particularly serious case of fulminant hepatic failure which should be
adequately assessed and reported to determine their exact incidence.
Description
Keywords
Lamotrigine, Hepatic failure
Citation
Gupta M C, Khanna J, Mathur R, Mittal N. Lamotrigine-induced fulminant hepatic failure: an unusual presentation. International Journal of Basic & Clinical Pharmacology. 2015 Mar-Apr; 4(2): 379-381.