Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam

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dc.contributor.authorEl Hanbally, Saberen_US
dc.contributor.authorEl Gendy, Hanemen_US
dc.contributor.authorEl Gendy, Hanemen_US
dc.contributor.authorEl Hewaity, Mohameden_US
dc.contributor.authorEl Hewaity, Mohameden_US
dc.date.accessioned2020-04-23T08:01:39Z
dc.date.available2020-04-23T08:01:39Z
dc.date.issued2020-04
dc.description.abstractBackground: Nonsteroidal anti-inflammatory drugs and antibiotics are commonly prescribed together. We aimed to study the kinetic profile of cefquinome (2 mg/kg b.wt.) following intramuscular administration of it alone and co-administered with meloxicam (0.2 mg/kg b.wt.) in goats.Methods: Five Egyptian Baladi goats, each goat was injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome into the deep gluteal muscle of hindquarter alone and then after fifteen days washout period, these animals also injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome preceded with meloxicam at the dose rate of 0.2 mg/kg b.wt. The serum concentrations of cefquinome were detected by high performance liquid chromatography, two compartment model.Results: Following a single dose intramuscular administration of cefquinome alone, peak plasma concentration (1.71�0189 ?g/ml) was obtained at 1.59�0038 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (area under concentration (AUC(0-inf)) of cefquinome were 0.4�0028 h, 0.068�78 l/h/kg, 9.21�178h and 29.36�78 礸.h.ml-1, respectively. Following a single dose intramuscular co-administration of cefquinome and meloxicam, peak plasma concentration (1.60�0124 ?g/ml) was obtained at 1.49�0092 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (AUC(0-inf)) of cefquinome were 0.396�006 h, 0.094�25 l/h/kg, 6.5�221 h and 21.38�696 礸/h/ml, respectively. Non significant alters were reported in the parameters following co-administration of Cefquinome with meloxicam.Conclusions: From our results, may be concluded that intramuscular administration of meloxicam may be successfully co-administrated with cefquinome for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypten_US
dc.identifier.affiliationsDepartment of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypten_US
dc.identifier.citationEl Hanbally Saber, El Gendy Hanem, El Gendy Hanem, El Hewaity Mohamed, El Hewaity Mohamed. Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 518-522en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200570
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201095en_US
dc.subjectKineticen_US
dc.subjectCefquinomeen_US
dc.subjectMeloxicamen_US
dc.subjectIntramuscularen_US
dc.subjectGoatsen_US
dc.titlePharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicamen_US
dc.typeJournal Articleen_US
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