An Epidemiological Study of AES (Acute Encephalitis Syndrome) Outbreak 2019 in Muzaffarpur District, Bihar, India

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dc.contributor.authorTopno, RKen_US
dc.contributor.authorPandey, Ken_US
dc.contributor.authorSiddiqui, NAen_US
dc.contributor.authorRabibas, Ven_US
dc.contributor.authorSinha, SKen_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorKumar, Men_US
dc.contributor.authorDikhit, MRen_US
dc.contributor.authorMadhukar, Men_US
dc.contributor.authorDinesh, DSen_US
dc.contributor.authorKesari, Sen_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorKumar, Sen_US
dc.contributor.authorAnsari, MZen_US
dc.contributor.authorMandal, Ren_US
dc.contributor.authorDas, Pen_US
dc.date.accessioned2025-08-13T09:08:25Z
dc.date.available2025-08-13T09:08:25Z
dc.date.issued2025-05
dc.description.abstractAcute encephalitis syndrome (AES) is a major public health concern in India, especially in Muzaffarpur, Bihar, as outbreaks of this neurological disorder have brought on significant morbidity and mortality. It is usually characterized by sudden fever, seizures, confusion, and altered mental status in children along with infectious agents, environmental factors, and malnutrition. It is evident during litchi harvest (April-June), affecting malnourished children from poor families. Among 622 AES cases from May till July 2019; a significant majority were found to have higher mortality and morbidity indices among female Scheduled Caste children. Access barriers in the social and cultural context delayed health care in the event of morbidity. Earlier speculation about associating litchi intake was set aside as most of affected children stayed far from orchards. Clinically, it manifests with fever starting suddenly associated with seizures, altered sensorium, hypoglycemia, hyponatremia, and elevated biomarkers CPK, LDH, and ammonia. High humidity and inadequate mosquito net use are linked. However, these observational studies could not show laboratory evidence of vectors of Japanese encephalitis. Priorities in action include strengthening surveillance, nutrition, education, and better health care access.en_US
dc.identifier.affiliationsDepartment of Epidemiology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Bio-informatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Vector Biology & Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Vector Biology & Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Vector Biology & Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Central Pathology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Vector Biology & Control, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-800007, Indiaen_US
dc.identifier.affiliationsDepartment of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, 800007, India.en_US
dc.identifier.citationTopno RK, Pandey K, Siddiqui NA, Rabibas V, Sinha SK, Kumar A, Kumar M, Dikhit MR, Madhukar M, Dinesh DS, Kesari S, Kumar V, Kumar S, Ansari MZ, Mandal R, Das P. An Epidemiological Study of AES (Acute Encephalitis Syndrome) Outbreak 2019 in Muzaffarpur District, Bihar, India. International Journal of TROPICAL DISEASE & Health. 2025 May; 46(5): 14-20en_US
dc.identifier.issn2278-1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251270
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber5en_US
dc.relation.volume46en_US
dc.source.urihttps://doi.org/10.9734/ijtdh/2025/v46i51653en_US
dc.subjectAcute encephalitis syndromeen_US
dc.subjectJapanese encephalitisen_US
dc.subjectMuzaffarpuren_US
dc.subjectmalnourished childrenen_US
dc.subjectdyselectrolytemiaen_US
dc.titleAn Epidemiological Study of AES (Acute Encephalitis Syndrome) Outbreak 2019 in Muzaffarpur District, Bihar, Indiaen_US
dc.typeJournal Articleen_US
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