Subacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity.

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dc.contributor.authorHazarika, Aen_US
dc.contributor.authorSarkar, S Nen_US
dc.date.accessioned2009-05-28T15:44:17Z
dc.date.available2009-05-28T15:44:17Z
dc.date.issued2001-11-22en_US
dc.description.abstractIn acute toxicity study, rats showed dose-dependent signs of cholinergic hyperactivity and behavioural alterations. Maximum intensity of symptoms was not associated with mortality. Oral LD50 was 1681 mg/kg. In subacute toxicity study, rats were orally administered 50, 100 or 200 mg/kg of anilofos once daily for 28 days. Signs and symptoms were observed mainly with 200mg/kg. At this dose, anilofos induced hypothermia and progressive weight loss. None of the anilofos-treated rats died. Weight of brain, lung, testis was not altered, while of liver, heart, spleen and kidney increased. Anilofos inhibited cholinesterase (ChE) activities of erythrocyte (41-67%), plasma (36%), blood (37-64%), brain (63-73%) and liver (28-48%). Total protein was decreased in plasma and liver. Results indicate moderate toxic potential of anilofos in mammals, substantial contribution of CNS-mediated effects in causing anilofos toxicity and no direct relationship between hypothermia and level of ChE inhibition.en_US
dc.description.affiliationDivision of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, India.en_US
dc.identifier.citationHazarika A, Sarkar SN. Subacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity. Indian Journal of Experimental Biology. 2001 Nov; 39(11): 1107-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62351
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAcetylcholinesterase --blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshCholinesterase Inhibitors --toxicityen_US
dc.subject.meshHerbicides --toxicityen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOrgan Size --drug effectsen_US
dc.subject.meshOrganophosphorus Compounds --toxicityen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleSubacute toxicity of anilofos, a new organophosphorus herbicide, in male rats: effect on some physical attributes and acetylcholinesterase activity.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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