Phospholipase A2 Inhibition and Antiinflammatory Activity of F4 Fraction of Total Ethereal Leaf Extract of Annona senegalensis Pers. (Annonaceae)

Simple item page
dc.contributor.authorSene, M.en_US
dc.contributor.authorBarboza, F. S.en_US
dc.contributor.authorNdong, A.en_US
dc.contributor.authorSarr, A.en_US
dc.contributor.authorWele, A.en_US
dc.contributor.authorBassene, E.en_US
dc.contributor.authorSY, G. Y.en_US
dc.date.accessioned2020-01-02T06:14:21Z
dc.date.available2020-01-02T06:14:21Z
dc.date.issued2018-12
dc.description.abstractAnnona senegalensis Pers. (ANNONACEAE) is a plant which is used in african traditional medicine for the treatment of various diseases. This study aimed to investigate the analgesic and anti-inflammatory activity of total ethereal leaf extract fractions of A. senegalensis. Compounds of methanolic fractions of ethereal leaf extract of A. senegalensis were separated by gel sephadex chromatography, in five fractions (F1, F2, F3, F4, F5). Experiments were performed in acetic acid-induced contortions in mice, carrageenan rat paw edema and phospholipase A2 inhibitory test. The methanolic fraction of total ethereal leaf extract (10 mg/kg, per os) significantly prevented the carrageenan inflammatory edema. The variation of edema is 22.31±3.35 %, 49.66±13.50 %, 52.10±10.02 % respectively at T1h, T3h and T5h. The increased edema after oral administration of F4 fraction administered at 300 µg/kg and 1 mg/kg per os is respectively 52.77±7.36 % and 33.81±6.94 %. The variation of edema in betamethasone group (1 mg/kg, per os) is 23.46±3.99 %. F4 fraction at 300 µg/kg, significantly inhibited 16.39 % of phospholipase A2 enzyme activity. F4 fraction (300 µg/kg, per os) also significantly prevented acetic acid-induced pain in mice. The number of abdominal contortions is 21 versus 72 in control group. F4 fraction compounds have a powerful analgesic and anti-inflammatory activity that involves phospholipase A2 inhibition, comparable to betamethasone profile on pain and inflammation.en_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Pharmacognosie et Botanique, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Chimie Organique et Thérapeutique, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Pharmacognosie et Botanique, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, FMPO, UCAD, BP 5005 Dakar-Fann, Senegal.en_US
dc.identifier.citationSene M., Barboza F. S., Ndong A., Sarr A., Wele A., Bassene E., SY G. Y.. Phospholipase A2 Inhibition and Antiinflammatory Activity of F4 Fraction of Total Ethereal Leaf Extract of Annona senegalensis Pers. (Annonaceae). European Journal of Medicinal Plants. 2018 Dec; 26(2): 1-9en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189456
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume26en_US
dc.source.urihttps://doi.org/10.9734/EJMP/2018/45788en_US
dc.subjectAnnona senegalensisen_US
dc.subjectleaf extracten_US
dc.subjectpainen_US
dc.subjectinflammationen_US
dc.subjectphospholipase A2en_US
dc.titlePhospholipase A2 Inhibition and Antiinflammatory Activity of F4 Fraction of Total Ethereal Leaf Extract of Annona senegalensis Pers. (Annonaceae)en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ejmp2018v26n2p1c.pdf
Size:
664.79 KB
Format:
Adobe Portable Document Format
Download
Collections
European Journal of Medicinal Plants