Role of mifepristone in preinduction cervical ripening and induction of labour at term: an observational study

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dc.contributor.authorSahoo, Ipsitaen_US
dc.contributor.authorAbichandani, Roshnien_US
dc.date.accessioned2024-09-24T10:58:44Z
dc.date.available2024-09-24T10:58:44Z
dc.date.issued2023-11
dc.description.abstractBackground: Induction implies stimulation of uterine contractions before spontaneous onset of labour. It is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. Of the various medical methods of induction, prostaglandins and oxytocin remain the most popular and acceptable methods in obstetric practice. Mifepristone is a steroid compound, with anti-progesterone activity. It increases uterine activity and causes cervical dilatation and effacement. We intend to study the role of oral mifepristone in preinduction cervical ripening and induction of labour in term pregnancies.Methods: In a prospective observational study carried out from Jan 2023 to June 2023 at a zonal hospital, 100 antenatal women at term with Bishop score less than 6 participated. Tablet mifepristone 200 mg single dose was given orally for induction. All patients were assessed after 24 hours for cervical ripening, need for augmentation, mode of delivery, maternal and neonatal outcome.Results: It was observed that there was a significant improvement in Bishop score 24 hours after giving mifepristone. Out of 100 women in the study, 82% delivered vaginally, 15% had caesarean section and 3% had instrumental delivery. 21% needed no second method of labour induction. 76% patients delivered within 48 hrs of ingestion of mifepristone. The majority of patients had good maternal and neonatal outcome.Conclusions: Mifepristone is an effective and safe method for preinduction cervical ripening and induction of labour in term pregnancies.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Military Hospital, Bikaner, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Military Hospital, Jaipur, Rajasthan, Indiaen_US
dc.identifier.citationSahoo Ipsita, Abichandani Roshni . Role of mifepristone in preinduction cervical ripening and induction of labour at term: an observational study . International Journal of Reproduction, Contraception, Obstetrics and Gynecology . 2023 Nov; 12(11): 3339-3342en_US
dc.identifier.issn2320-1770
dc.identifier.issn2320-1789
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/234688
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-1770.ijrcog20233305en_US
dc.subjectBishop scoreen_US
dc.subjectInduction of labouren_US
dc.subjectMifepristoneen_US
dc.titleRole of mifepristone in preinduction cervical ripening and induction of labour at term: an observational studyen_US
dc.typeJournal Articleen_US
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