Role of mifepristone in preinduction cervical ripening and induction of labour at term: an observational study
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Date
2023-11
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Medip Academy
Abstract
Background: Induction implies stimulation of uterine contractions before spontaneous onset of labour. It is indicated when the benefits to either mother or fetus outweigh those of pregnancy continuation. Of the various medical methods of induction, prostaglandins and oxytocin remain the most popular and acceptable methods in obstetric practice. Mifepristone is a steroid compound, with anti-progesterone activity. It increases uterine activity and causes cervical dilatation and effacement. We intend to study the role of oral mifepristone in preinduction cervical ripening and induction of labour in term pregnancies.Methods: In a prospective observational study carried out from Jan 2023 to June 2023 at a zonal hospital, 100 antenatal women at term with Bishop score less than 6 participated. Tablet mifepristone 200 mg single dose was given orally for induction. All patients were assessed after 24 hours for cervical ripening, need for augmentation, mode of delivery, maternal and neonatal outcome.Results: It was observed that there was a significant improvement in Bishop score 24 hours after giving mifepristone. Out of 100 women in the study, 82% delivered vaginally, 15% had caesarean section and 3% had instrumental delivery. 21% needed no second method of labour induction. 76% patients delivered within 48 hrs of ingestion of mifepristone. The majority of patients had good maternal and neonatal outcome.Conclusions: Mifepristone is an effective and safe method for preinduction cervical ripening and induction of labour in term pregnancies.
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Keywords
Bishop score, Induction of labour, Mifepristone
Citation
Sahoo Ipsita, Abichandani Roshni . Role of mifepristone in preinduction cervical ripening and induction of labour at term: an observational study . International Journal of Reproduction, Contraception, Obstetrics and Gynecology . 2023 Nov; 12(11): 3339-3342