Comparison of Ofloxacin & Ornidazole with Probiotic versus Doxycycline & Metronidazole for the Outpatient Treatment of Pelvic Inflammatory Disease
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Date
2007-04
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Abstract
The aim of the study was to compare the efficacy and cost effectiveness of ofloxacin, ornidazole, serratiopeptidase
and Saccharomyces Boulardii combination with traditional doxycycline and metronidazole combination with
serratiopeptidase in the outpatient management of pelvic inflammatory disease. A total of one hundred and
ninety three women presenting with symptoms of pelvic inflammatory disease (PID) confirmed to be a case
of PID on clinical examination were randomized to one of the two treatments. No investigations were performed
to cut the cost and to avoid loss of follow up. A total of 98 women (Group I) were prescribed ofloxacin
(400mg), ornidazole (500mg), Serratiopeptidase (10mg), Lactic acid bacillus 60 million spores and
Saccharomyces Boulardii 2 million spores once a day for 10 days while a total of ninety five women (group II)
were given a 10 day course of doxycycline (100 mg BD) with metronidazole (400mg TDS) along with 10mg
of serratiopeptidase once daily. All women were seen after 2 weeks for relief of symptoms and possible side
effects. The results were then analyzed. It was found that although the efficacy of both drug regimens was
similar. The incidence of gastrointestinal side-effects mainly were less in group I. This was probably due to the
addition of probiotic Saccharomyces Boulardii and lactic acid bacillus. The once daily administration led to
better compliance in the first group.
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Keywords
Pelvic inflammatory disease, Syndromic approach, Combination antimicrobial kit
Citation
Sharma J B, Chanana Charu, Kumar Sunesh, Roy Kallol, Malhotra Neena. Comparison of Ofloxacin & Ornidazole with Probiotic versus Doxycycline & Metronidazole for the Outpatient Treatment of Pelvic Inflammatory Disease. JK Science Journal of Medical Education and Research. 2007 Apr-June;9(2): 66-69