Abnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia.

dc.contributor.authorKumar, A
dc.contributor.authorDaniel, S
dc.contributor.authorAgarwal, S S
dc.contributor.authorGupta, C M
dc.date.accessioned2015-07-24T12:19:58Z
dc.date.available2015-07-24T12:19:58Z
dc.date.issued1987-03
dc.description.abstractThe membrane phospholipid organisation in the red cells of humans suffering from chronic myeloid leukaemia has been analysed using the amino-group labelling reagent trinitrobenzenesulphonic acid and the fluid-sensing fluorophore, Merocyanine 540. Unlike the normal human erythrocytes, trinitrobenzenesulphonic acid in intact chronic myeloid leukaemia erythrocytes modified about 30% phosphatidylserine, under controlled conditions. Also, the chronic myeloid laukaemia red cells, but not the normal cells, were found to bind the fluorescent dye Merocyanine 540. These results demonstrate that loss of the transmembrane phospholipid asymmetry in chronic myeloid leukaemia erythrocytes is accompanied by an enhancement in the outer surface fluidity and, therefore, suggest that the red cells membrane phase-state asymmetry originates probably from the asymmetric arrangements of phospholipids across the membrane bilayer.en_US
dc.identifier.citationKumar A, Daniel S, Agarwal S S, Gupta C M. Abnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia. Journal of Biosciences. 1987 Mar; 11(1-4): 543-548.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/160551
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jarch/jbiosci/11/543-548.pdfen_US
dc.subjectPhospholipid asymmetryen_US
dc.subjecterythrocytesen_US
dc.subjectphase-state asymmetryen_US
dc.subjectchronic myeloid leukaemiaen_US
dc.titleAbnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia.en_US
dc.typeArticleen_US
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