In vitro schizontocidal activity of standard antimalarial drugs on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum.

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dc.contributor.authorSharma, Pen_US
dc.contributor.authorPillai, C Ren_US
dc.contributor.authorDevi Sharma, Jen_US
dc.date.accessioned2009-05-28T15:13:26Z
dc.date.available2009-05-28T15:13:26Z
dc.date.issued2000-11-09en_US
dc.description.abstractThe expanding foci of multiple drug resistant malaria and emergence of different strains requires the reassessment of antimalarial activity with various drugs. In vitro response of a chloroquine sensitive and a chloroquine resistant isolate of P. falciparum to a group of 6 quinine derived and 3 artemisinin derived standard drugs has been screened, to evaluate schizontocidal activity of the drugs. In a conventional test system the IC50s were derived from the log dose response curves and evaluated by a rigorous statistical interpretation. Analysis by Tukey's test was significant for the quinine related drugs (Q < or = 0.01) and excludes the statistical significance of artemisinin related drugs in these isolates. The dose-responses of these two isolates vary with quinine derivatives, with some overlap at lower doses for the sensitive isolate than for the resistant one which manifests at higher doses.en_US
dc.description.affiliationSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.en_US
dc.identifier.citationSharma P, Pillai CR, Devi Sharma J. In vitro schizontocidal activity of standard antimalarial drugs on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum. Indian Journal of Experimental Biology. 2000 Nov; 38(11): 1129-33en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61713
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimalarials --pharmacologyen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.titleIn vitro schizontocidal activity of standard antimalarial drugs on chloroquine-sensitive and chloroquine-resistant isolates of Plasmodium falciparum.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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