Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats.

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dc.contributor.authorSultana, Sarwaten_US
dc.contributor.authorAhmad, Salahuddinen_US
dc.contributor.authorKhan, Naghmaen_US
dc.contributor.authorJahangir, Tamannaen_US
dc.date.accessioned2009-05-28T14:58:16Z
dc.date.available2009-05-28T14:58:16Z
dc.date.issued2005-05-20en_US
dc.description.abstractA single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in reduced glutathione, glutathione peroxidase and glutathione reductase. It also caused enhancement in the levels of lipid peroxidation (LPO) and DNA synthesis. There was also pathological deterioration of hepatic tissue as evident from multivacuolated hepatocytes containing fat globules around central vein. The pretreatment of E. officinalis for 7 consecutive days showed a profound pathological protection to liver cell as depicted by univacuolated hepatocytes. Pretreatment with E. officinalis at doses of 100 and 200 mg/kg body weight, prior to CCl4 intoxication showed significant reduction in the levels of SGOT, SGPT, LDH, glutathione-S-transferase, LPO and DNA synthesis. There was also increase in reduced glutathione, glutathione peroxidase and glutathione reductase. The results suggest that E. officinalis inhibits hepatic toxicity in Wistar rats.en_US
dc.description.affiliationSection of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110 062, India. sarwat786@rediffmail.comen_US
dc.identifier.citationSultana S, Ahmad S, Khan N, Jahangir T. Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian Journal of Experimental Biology. 2005 May; 43(5): 430-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61391
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbon Tetrachloride --toxicityen_US
dc.subject.meshDNA Replication --drug effectsen_US
dc.subject.meshHepatitis, Toxic --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhyllanthus emblica --chemistryen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleEffect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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