Drug Delivery Through Blood Brain Barrier: Taming the Bottleneck in CNS Therapeutics
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Date
2018-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Dr. J.S. Sodhi Memorial Educational Society
Abstract
Although many agents have therapeutic potentials for Central Nervous System (CNS) diseases, few of these agents have been clinically used because of the brain barriers. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. Different strategies for efficient CNS delivery have been studied. This review presents the current approaches to facilitate penetration across these barriers for enhanced drug delivery to the CNS.
Description
Keywords
Blood Brain Barrier, CNS Drug Delivery, Pharmacy and Pharmacology
Citation
Sehgal VK, Singla R. Drug Delivery Through Blood Brain Barrier: Taming the Bottleneck in CNS Therapeutics. International Journal of Medical and Dental Sciences. 2018 Jul; 7(2): 1653-1656