Anti-tumour activity of Ruta graveolens extract.

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dc.contributor.authorPreethi, K Cen_US
dc.contributor.authorKuttan, Girijaen_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2009-05-27T17:46:21Z
dc.date.available2009-05-27T17:46:21Z
dc.date.issued2006-07-25en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractAn extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A homeopathic preparation of Ruta graveolens (200 c) was equally effective. Neither was effective for reducing already developed tumours. The Ruta graveolens extract was found to scavenge hydroxyl radicals and inhibit lipid peroxidation at low concentrations. However, at higher concentrations the extract acted as a prooxidant as inhibition of lipid peroxidation and scavenging of hydroxyl radical was minimal. These data indicates that the prooxidant activity of Ruta graveolens may be responsible for the cytocidal action of the extract and its ability to produce tumour reduction.en_US
dc.description.affiliationAmala Cancer Research Centre, Amala Nagar, Thrissur, Kerala-680555, India.en_US
dc.identifier.citationPreethi KC, Kuttan G, Kuttan R. Anti-tumour activity of Ruta graveolens extract. Asian Pacific Journal of Cancer Prevention. 2006 Jul-Sep; 7(3): 439-43en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37856
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents, Phytogenic --therapeutic useen_US
dc.subject.meshCarcinoma, Ehrlich Tumor --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFree Radical Scavengers --pharmacologyen_US
dc.subject.meshHydroxyl Radicalen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLymphoma --pathologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRuta --chemistryen_US
dc.subject.meshTumor Cells, Cultured --drug effectsen_US
dc.subject.meshXenograft Model Antitumor Assaysen_US
dc.titleAnti-tumour activity of Ruta graveolens extract.en_US
dc.typeJournal Articleen_US
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