Evaluation of anxiolytic effect of aqueous extract of Garcinia indica seeds using open field test

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dc.contributor.authorRane, Pen_US
dc.contributor.authorKewlani, Aen_US
dc.contributor.authorVerma, Ren_US
dc.contributor.authorBhalerao, Sen_US
dc.contributor.authorNayak, Uen_US
dc.contributor.authorMahadkar, Pen_US
dc.date.accessioned2025-06-18T11:23:09Z
dc.date.available2025-06-18T11:23:09Z
dc.date.issued2025-06
dc.description.abstractBackground: Anxiety is a common psychiatric condition frequently encountered in medical practice. While benzodiazepines like Diazepam are widely used as anxiolytics, they come with long-term adverse effects. Garcinia indica (Kokum), a natural herb, is believed to have anxiolytic properties without these drawbacks. This study aimed to evaluate its anxiolytic potential as a safer alternative. Method: Wistar albino rats (n=32) were divided into four groups (8 per group) and administered orally with distilled water (0.5 ml), Diazepam (1 mg/kg), Garcinia indica (1.75 gm/kg), and Garcinia indica (3.5 gm/kg), respectively. Anxiety was assessed using the open field test, measuring parameters like the number of lines crossed, central square entries, rearing, grooming, immobility, and urination. Data were analyzed using one-way ANOVA followed by Tukey’s test. Results: Both doses of Garcinia indica and Diazepam significantly increased central square crossings and improved behavior such as rearing, grooming, and immobility. However, Garcinia indica did not significantly affect urination or number of lines crossed compared to the control. Diazepam significantly reduced number of lines crossed compared to Garcinia indica (3.5 gm/kg). Conclusion: Garcinia indica demonstrated significant anxiolytic effects comparable to Diazepam, suggesting its potential as a safer alternative for anxiety management.en_US
dc.identifier.affiliationsDepartment of Pharmacology, K. J. Somaiya Medical College, Hospital and Research Centre, Everard Nagar, Sion (E), Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Shri Balaji Institute of Medical Science, Mowa, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Shri Balaji Institute of Medical Science, Mowa, Raipur, Chhattisgarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, K. J. Somaiya Medical College, Hospital and Research Centre, Everard Nagar, Sion (E), Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Topiwala National Medical College and B.Y.L. Nair Charitable Hospital, Dr. A. L. Nair Road, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationRane P, Kewlani A, Verma R, Bhalerao S, Nayak U, Mahadkar P. Evaluation of anxiolytic effect of aqueous extract of Garcinia indica seeds using open field test. International Journal of Basic & Clinical Pharmacology. 2025 Jun; 14(3): 382-387en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/248640
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20251064en_US
dc.subjectAnxiolytic effecten_US
dc.subjectDiazepamen_US
dc.subjectGarcinia indicaen_US
dc.subjectOpen field testen_US
dc.subjectLocomotor activity and behavioural responseen_US
dc.titleEvaluation of anxiolytic effect of aqueous extract of Garcinia indica seeds using open field testen_US
dc.typeJournal Articleen_US
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