Serum and Erythrocyte Magnesium levels in Offsprings of Essential Hypertensive Parents.
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Date
2012
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Abstract
Hypertension is an important public health challenge worldwide, 95% of which are primary
or essential hypertension, where the exact causes are not known. It has been thought that
magnesium level has an association with hypertension and plays role in the pathogenesis of
essential hypertension. Several evidences suggested that decreased magnesium level may be
a significant modifiable risk factor for developing essential hypertension. To explore the
relationship between serum and erythrocyte magnesium level with blood pressure, this case
control study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib
Medical University (BSMMU), during the year 2006. Thirty offsprings of essential hypertensive
parents were taken as cases and 30 age and sex-matched offsprings of normotensive parents were
taken as controls. Serum & erythrocyte magnesium were measured by colorimetric Calmagite
method. Significantly lower serum magnesium level (mg/dl) was found in cases than that of
controls (1.90±0.210 vs 2.13±0.366, p<0.01) and erythrocyte magnesium (mg/dl) was also
found to be lower in cases when compared with that of controls (4.46±0.699 vs 5.43±0.775,
p<0.001). Mean systolic and diastolic blood pressure were found to be significantly higher
(p<0.01) in cases as compared to controls. Though it is difficult to draw any definite
conclusion, it may be assumed that, a hereditary predisposition to hypertension may be related to
magnesium metabolism and magnesium deficiency might have a role in the future development
of hypertension in the offsprings of essential hypertensive parents.
Description
Keywords
Essential Hypertension, Serum Magnesium, Erythrocyte Magnesium
Citation
Ferdousi S, Sultana1 N, Rahman M H, Haque R, Khanam M, Howlader M H, Arslan M I. Serum and Erythrocyte Magnesium levels in Offsprings of Essential Hypertensive Parents. Bangladesh Journal of Medical Biochemistry. 2012; 5(2): 40-43.