Bacteriological Profiles of Pyogenic Wound Infection among Adults with Antibiotic Susceptibility Pattern at a Tertiary Hospital in Nigeria

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dc.contributor.authorOnwuezobe, I. A.en_US
dc.contributor.authorMatthew, P. C.en_US
dc.contributor.authorOyoyo, A.O.en_US
dc.date.accessioned2020-10-16T08:45:04Z
dc.date.available2020-10-16T08:45:04Z
dc.date.issued2020-09
dc.description.abstractAims:A wide variety of aerobic and anaerobic bacteria either singly or in combination has been implicated in pyogenic wound infection and this has been associated with treatment failures due to antibiotic resistance. This study aims at investigating the agentsof pyogenic wound infection and their antibiotic susceptibility.Study Design:A descriptive cross-sectional study conducted at the only tertiary Teaching Hospital in Uyo, Nigeria and carried out on 136 wound samples.Place and Duration of Study: University of Uyo Teaching Hospital, Uyo, Nigeria,between April and October, 2018.Methodology: Aspirated pus or wound swab samples were collected and inoculated on two separate agar plates containing 25% Sheep Blood and incubated aerobically and anaerobically at 37°C for 48 –72 hours. Identification of isolates was performed following standard procedures. Data obtained were analyzed using SPSS software. Results:Of the 136 collected wound samples from 76 (55.9%) males and 60 (44.1%) females patients fromages 20 to 70 years and above, 127 (93.4%) had growth of different bacterial isolates totaling 214 in number. Among these were aerobes 132 (61.6%) anaerobes 82 (38.4%). The Gram-negative aerobes had the highest prevalence 81 (37.9%), while the Gram-positive anaerobes 20 (9.4%) was the least prevalent. Staphylococcus aureus,44 (86.3%) and Pseudomonas aeruginosa, 24 (29.6%), were the predominant Gram-positive and Gram-negative aerobes respectively. Peptococci spp. 8 (40%) andBacteriodes fragilis28 (54.9%)were the predominant Gram-positive and Gram-negative anaerobes respectively.Some rarely reported pathogens revealed include Acinetobacter iwoffi, Enterobacter cloacaeand Stenotrophomonas maltophilia1(1.2%) and they showed 100% resistance to all tested antibiotics. The majority of the Gram-positive aerobes 29 (56.9%) were Vancomycin resistant and there was also an increasing prevalence of Methicillin resistant Staphylococcus aureus(45%).Conclusion:The bacterial agents causing pyogenic wound infection in Uyo comprised of 61.6% aerobes and 38.4% anaerobes. Some rarely reported bacteria such as Enterobacter cloacaeand A. iwofiiimplicated in the infections were resistant to all commonly used antibiotics including Imipenem, a reserved antibiotic. Staphylococcus aureuswas the commonest cause of pyogenic wound infection and up to 45% of them were Methicillin resistant.en_US
dc.identifier.affiliationsDepartment of Medical Microbiology and Parasitology, University of Uyo, Nigeriaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology and Parasitology, University of Uyo, Nigeriaen_US
dc.identifier.affiliationsDepartment of Anaestiology, University of Uyo Teaching Hospital, Nigeriaen_US
dc.identifier.citationOnwuezobe I. A., Matthew P. C., Oyoyo A.O.. Bacteriological Profiles of Pyogenic Wound Infection among Adults with Antibiotic Susceptibility Pattern at a Tertiary Hospital in Nigeria. International Journal of TROPICAL DISEASE & Health. 2020 Sep; 41(13): 39-50en_US
dc.identifier.issn2278–1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209722
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber13en_US
dc.relation.volume41en_US
dc.source.urihttps://dx.doi.org//10.9734/IJTDH/2020/v41i1330346en_US
dc.subjectBacteriological profileen_US
dc.subjectpyogenic wounden_US
dc.subjectantibiotic susceptibilityen_US
dc.subjecttertiary hospitalen_US
dc.titleBacteriological Profiles of Pyogenic Wound Infection among Adults with Antibiotic Susceptibility Pattern at a Tertiary Hospital in Nigeriaen_US
dc.typeJournal Articleen_US
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