Antioxidant activity of glycowithanolides from Withania somnifera.

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dc.contributor.authorBhattacharya, S Ken_US
dc.contributor.authorSatyan, K Sen_US
dc.contributor.authorGhosal, Sen_US
dc.date.accessioned2009-05-28T10:54:23Z
dc.date.available2009-05-28T10:54:23Z
dc.date.issued1997-03-01en_US
dc.description.abstractAntioxidant activity of active principles of Withania somnifera, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, was investigated for their effects on rat brain frontal cortical and striatal concentrations of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). Results were compared with effects induced by deprenyl, an agent with well documented antioxidant activity. Active glycowithanolides of W. somnifera (WSG) (10 and 20 mg/kg, i.p.), administered once daily for 21 days, induced a dose-related increase in SOD, CAT and GPX activity in frontal cortex and striatum, which was statistically significant on days 14 and 21, except with the lower dose of WSG on GPX activity, where the effect was evident only on day 21. The data were comparable to those induced by deprenyl (2 mg/kg/day, i.p.) with respect to SOD, CAT and GPX activities, which were evident by day 14. These findings are consistent with the therapeutic use of W. somnifera as an Ayurvedic rasayana and medhyarasayana. Antioxidant effect of active principles of W. somnifera may explain, at least in part, the reported antistress, immunomodulatory, cognition-facilitating, anti-inflammatory and anti-aging effects produced by them in experimental animals, and in clinical situations.en_US
dc.description.affiliationDepartment of Pharmacology, Banaras Hindu University, Varanasi, India.en_US
dc.identifier.citationBhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian Journal of Experimental Biology. 1997 Mar; 35(3): 236-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55965
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --pharmacologyen_US
dc.subject.meshBrain --drug effectsen_US
dc.subject.meshErgosterol --analogs & derivativesen_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshPlants, Medicinal --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSitosterols --pharmacologyen_US
dc.titleAntioxidant activity of glycowithanolides from Withania somnifera.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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