Evaluation of cytotoxic and antioxidant activity of different fractions of methanolic extract of Baccaurea ramiflora (Lour.) fruits.

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dc.contributor.authorAmin, Roksana
dc.contributor.authorNabi, Md Nahidun
dc.date.accessioned2015-12-14T03:59:03Z
dc.date.available2015-12-14T03:59:03Z
dc.date.issued2015
dc.description.abstractChloroform and petroleum ether soluble fractions of the crude methanolic extract of the fruits of Baccaurea ramiflora (Lour.) have been investigated for the evaluation of cytotoxic and antioxidant activity. Brine shrimp lethality bioassay was used to evaluate the cytotoxic activity and free radical scavenging activity method was used to evaluate antioxidant activity. In brine shrimp lethality bioassay, the chloroform soluble fraction showed greater cytotoxic activity (LC50 value 74.2 μg/ml) than petroleum ether soluble fraction (LC50 value 129 μg/ml) compared to the standard drug vincristine sulfate (LC50 value 0.54 μg/ml). In free radical scavenging activity method (DPPH assay method), the chloroform soluble fraction showed greater antioxidant activity (IC50 value 49.78 μg/ml) than petroleum ether soluble fraction (IC50 value 75.31 μg/ml) compared to the standard antioxidant butylated hydroxytoluene (IC50 value 24.51μg/ml). This study reveals that Baccaurea ramiflora fruit possesses cytotoxic and antioxidant activity hence can be a potential source for the isolation of active principle(s) for different therapies.en_US
dc.identifier.citationAmin Roksana, Nabi Md Nahidun. Evaluation of cytotoxic and antioxidant activity of different fractions of methanolic extract of Baccaurea ramiflora (Lour.) fruits. International Current Pharmaceutical Journal. 2015; 4(6): 386-389.en_US
dc.identifier.issn2224-9486
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/167996
dc.language.isoenen_US
dc.source.urihttps://www.banglajol.info/index.php/ICPJ/article/view/23288en_US
dc.subjectBaccaurea ramifloraen_US
dc.subjectcytotoxic activityen_US
dc.subjectbrine shrimp lethality bioassayen_US
dc.subjectantioxidant activityen_US
dc.subjectDPPH free radical scavenging assayen_US
dc.titleEvaluation of cytotoxic and antioxidant activity of different fractions of methanolic extract of Baccaurea ramiflora (Lour.) fruits.en_US
dc.typeArticleen_US
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