Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat), a herbal preparation.

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dc.contributor.authorKulkarni, S Ken_US
dc.contributor.authorSharma, Aen_US
dc.date.accessioned2009-05-28T14:40:16Z
dc.date.available2009-05-28T14:40:16Z
dc.date.issued1994-12-01en_US
dc.description.abstractAbrupt cessation of chronic treatment of diazepam (20 mg/kg/day for 21 days) produced withdrawal reactions. BR 16-A, a multicomponent herbal preparation shown to reverse the withdrawal reactions to opiates was studied against diazepam induced withdrawal reactions in mice. Acute dose of diazepam (20 mg/kg) produced a decrease in the ambulatory and total activity. However, chronic administration for 21 days produced tolerance and no significant change in the ambulatory and total activity. On abrupt termination of diazepam treatment after 21 days, the animals showed anxiety and excitement as there was an increase in ambulatory and total activity. The withdrawal excitement was highest at 72 hr of the last dose of diazepam. Concomittant administration of BR 16-A (100 and 500 mg/kg) reversed the acute effect of diazepam in a dose dependent manner. Similarly, chronic administration of BR 16-A (100 and 500 mg/kg/day for 21 days) with diazepam (20 mg/kg/day for 21 days) also reversed the withdrawal induced hyperambulation and total activity. Chronic administration of BR 16-A per se had no significant effect on the ambulatory and total activity, however, in acute doses, BR 16-A (100 and 500 mg/kg) produced a dose dependent increase in the ambulatory and total activity. BR 16-A with its CNS profile of activity could be a useful preparation in the management of substances of abuse.en_US
dc.description.affiliationDepartment of Pharmaceutical Sciences, Panjab University, Chandigarh, India.en_US
dc.identifier.citationKulkarni SK, Sharma A. Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat), a herbal preparation. Indian Journal of Experimental Biology. 1994 Dec; 32(12): 886-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61009
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDiazepam --adverse effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHyperkinesis --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshMedicine, Ayurvedicen_US
dc.subject.meshMiceen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshPsychotropic Drugs --therapeutic useen_US
dc.subject.meshSubstance Withdrawal Syndrome --drug therapyen_US
dc.titleReversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat), a herbal preparation.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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