Immunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally.

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dc.contributor.authorDogra, Shashien_US
dc.contributor.authorWaseem, Mohden_US
dc.contributor.authorKhanna, Ashok Kumaren_US
dc.contributor.authorKaw, Jawahir Lalen_US
dc.date.accessioned2009-05-28T15:51:52Z
dc.date.available2009-05-28T15:51:52Z
dc.date.issued2002-03-15en_US
dc.description.abstractRats were intratracheally (i.t.) exposed to 36.5 or 27.5 microg of cadmium (Cd) as soluble cadmium chloride (CdCl2) and insoluble cadmium oxide (CdO) salts. The retention of metal in lungs, liver and kidney was assessed by atomic adsorption spectrophotometer. The animals were intraperitoneally (i.p.) primed with sheep red blood cells (SRBC) and assessed for the number of antibody forming cells in lung associated lymph nodes (LALN) and spleen. Both the compounds had similar retention of metal in lungs but CdO induced more pulmonary inflammatory and degradative changes than CdCl2. The larger influx of polymorphonuclear cells (PMNs) following CdO exposure appears to be due to the absence of protection afforded by Cd induced metallothionein cytoplasmic protein while the Cd metallothionein complex formed in the case of CdCl2 is more protective. However both forms of Cd had similar local immunosuppressive potential but CdO had more prolonged suppressive effect.en_US
dc.description.affiliationIndustrial Toxicology Research Centre, Post Box, No. 80, M.G. Marg, Lucknow 226001, India. itrc@sanchar net.comen_US
dc.identifier.citationDogra S, Waseem M, Khanna AK, Kaw JL. Immunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally. Indian Journal of Experimental Biology. 2002 Mar; 40(3): 262-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62511
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCadmium Chloride --administration & dosageen_US
dc.subject.meshCalcium Compounds --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunosuppressive Agents --administration & dosageen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshLung --drug effectsen_US
dc.subject.meshLymph Nodes --drug effectsen_US
dc.subject.meshOxides --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshSolubilityen_US
dc.subject.meshTracheaen_US
dc.titleImmunotoxicity of soluble and insoluble salts of cadmium instilled intratracheally.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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