Cross sectional study on different doses of acenocoumarol with INR in a tertiary care hospital

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dc.contributor.authorE., Keerthien_US
dc.contributor.authorS., Bhuvaneshwarien_US
dc.contributor.authorMurugesan, Periyanarkunan Ramaiyaen_US
dc.contributor.authorT., Priyadharshinien_US
dc.contributor.authorP., Sri Subikshaen_US
dc.date.accessioned2020-04-23T07:51:32Z
dc.date.available2020-04-23T07:51:32Z
dc.date.issued2018-09
dc.description.abstractBackground: It is of high value to be assess the relationship between doses of Acenocoumarol and the INR values to offer better patient care. Since Acenocoumarol is a commonly used drug with a narrow therapeutic range it is essential to monitor the variations encountered in response to it to avoid drastic complications and to provide better health care. Aim: The aim of this study is to compare the INR values with different doses of Acenocoumarol, to compare the association of dose of Acenocoumarol with their respective INR and to find out the occurrence of bleeding with different doses of Acenocoumarol.Methods: The study was conducted in a Tertiary care hospital. 40 patients taking Acenocoumarol were recruited in the study. Relevant details like age, weight, dose of Acenocoumarol, INR and other concomitant drugs were obtained in a prospective manner. Correlation of dose of Acenocoumarol with respective INR was done by simple linear regression.Results: The relationship between dose and INR was analyzed using Simple linear regression and the scatter plot revealed no significant correlation between the dose and INR values. There is a lot of inter-individual variability in the dose response and thereafter the INR values.Conclusions: The dose of Acenocoumarol cannot predict INR values. Patient can ideally be started treatment on a low dose of Acenocoumarol and based on the INR values, dose can be titrated. There is a need for consideration of other factors which influence the dose and INR values.en_US
dc.identifier.affiliationsMBBS Student, PSGIMS&R, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, KFMSR, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiothoracic Surgery, PSGIMS&R, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.citationE. Keerthi, S. Bhuvaneshwari, Murugesan Periyanarkunan Ramaiya, T. Priyadharshini, P. Sri Subiksha. Cross sectional study on different doses of acenocoumarol with INR in a tertiary care hospital. International Journal of Basic & Clinical Pharmacology. 2018 Sep; 7(9): 1738-1741en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199824
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20183481en_US
dc.subjectAcenocoumarolen_US
dc.subjectDifferent dosesen_US
dc.subjectINRen_US
dc.titleCross sectional study on different doses of acenocoumarol with INR in a tertiary care hospitalen_US
dc.typeJournal Articleen_US
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