Immunohistochemical evaluation of expression of cytokeratin 19 in different histological grades of leukoplakia and oral squamous cell carcinoma.

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dc.contributor.authorRam Prassad, V V Sen_US
dc.contributor.authorNirmala, N Raoen_US
dc.contributor.authorKotian, M Sen_US
dc.date.accessioned2009-05-28T07:39:32Z
dc.date.available2009-05-28T07:39:32Z
dc.date.issued2005-01-27en_US
dc.description.abstractRecent progress in understanding the biology of keratins together with the development of monoclonal antibodies to individual keratin proteins provide the foundation for studying the keratin expression in normal and pathological oral epithelia. Cytokeratin (CK) alterations have been reported in carcinomas and these have been associated with specific aspects of tumour behaviour. Immunohisto-chemistry with monospecific CK19 antibody was used to study the expression pattern in normal mucosa, dysplasias, and oral squamous cell carcinomas (OSCC). In non-keratinzed normal mucosa, CK19 was detected in the basal cell layer, while in dysplasias (diagnosed in H and E stained sections, mild-severe) stained strongly for CK 19 in the basal and supra basal cell layers indicating layer specificity for CK 19 expression. In OSCC, in the number of CK19 labelled cells increased from well to poorly differentiated tumour. Thus the results of the present study indicate an alteration in synthesis of keratin proteins when exposed to carcinogens.en_US
dc.description.affiliationDepartment of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Affiliated to Manipal Academy of Higher Education, India.en_US
dc.identifier.citationRam Prassad VV, Nirmala NR, Kotian MS. Immunohistochemical evaluation of expression of cytokeratin 19 in different histological grades of leukoplakia and oral squamous cell carcinoma. Indian Journal of Dental Research. 2005 Jan-Mar; 16(1): 6-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/51478
dc.language.isoengen_US
dc.source.urihttps://www.ijdr.inen_US
dc.subject.meshAntibodies, Monoclonal --diagnostic useen_US
dc.subject.meshCarcinoma, Squamous Cell --pathologyen_US
dc.subject.meshColoring Agents --diagnostic useen_US
dc.subject.meshEpithelium --pathologyen_US
dc.subject.meshFluorescent Dyes --diagnostic useen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshKeratins --analysisen_US
dc.subject.meshLeukoplakia, Oral --pathologyen_US
dc.subject.meshMouth Mucosa --pathologyen_US
dc.subject.meshMouth Neoplasms --pathologyen_US
dc.titleImmunohistochemical evaluation of expression of cytokeratin 19 in different histological grades of leukoplakia and oral squamous cell carcinoma.en_US
dc.typeJournal Articleen_US
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