Wound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-α.

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dc.contributor.authorGoel, Anjana
dc.contributor.authorKumar, Sandeep
dc.contributor.authorSingh, Dilip Kumar
dc.contributor.authorBhatia, Ashok Kumar
dc.date.accessioned2013-02-07T06:28:36Z
dc.date.available2013-02-07T06:28:36Z
dc.date.issued2010-04
dc.description.abstractOcimum sanctum, a well known herb in Indian medicine, possesses various therapeutic properties including healing properties and cytokine induction. Wound healing activity of cold aqueous extract of O. sanctum leaves along with its effect on tumor necrosis factor- (TNF-α) was assessed using excision model of wound repair in Wistar albino rats. After application of the O. sanctum extract, rate of epithelization with an increase in wound contraction was observed. In animals, treated with 10% O. sanctum extract in petroleum jelly, wound healing was faster as compared to control group which were treated with petroleum jelly alone but significant accelerated healing was noticed in animals which in addition to the topical application of 10% extract of O. sanctum, were prefed with 250mg/kg body weight of aqueous O. sanctum extract daily for 20 consecutive days. During wound healing phase TNF-α level was found to be up regulated by O. sanctum treatment. Early wound healing may be pronounced due to O. sanctum extract, by elevating TNF-α production.en_US
dc.identifier.citationGoel Anjana, Kumar Sandeep, Singh Dilip Kumar, Bhatia Ashok Kumar. Wound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-α. Indian Journal of Experimental Biology. 2010 Apr; 48(4): 402-406.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144985
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/7652en_US
dc.subjectCytokine inductionen_US
dc.subjectOcimum sanctumen_US
dc.subjectTNF-αen_US
dc.subjectWound healingen_US
dc.titleWound healing potential of Ocimum sanctum Linn. with induction of tumor necrosis factor-α.en_US
dc.typeArticleen_US
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