Relationship between estrogen and lipid profile status in postmenopausal women.
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Date
2012-07
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Abstract
Menopause is the permanent cessation of mensturation due to loss of ovarian follicular function,
which results in decreased production of estradiol and other hormones. Decreased levels of estrogen leads to
variations in lipid profile leading to atherosclerosis thus by increasing risk of coronary artery disease in post
menopausal women. The present study was conducted to evaluate the relationship between serum estradiol and lipid
profile status in postmenopausal women to assess risk for coronary artery disease. Study includes 70 subjects, 30
healthy premenopausal women (25-40yrs) and the healthy postmenopausal women in the age group of (55 –
65yrs).Serum estradiol and lipid profile status were estimated in both cases and controls. Reduced estradiol
(P0.0001) in post menopausal women and p value is highly significant for total cholesterol, triglycerides, low density
lipoproteins. Conclusion: Thus the study outlines that the low levels of estrogen exerts a significant effect on the
plasma lipids and lipoprotein metabolism. The risk of coronary artery disease increases in women after menopause.
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Keywords
TC-total cholesterol, TG-Triglycerides, HDL-High density lipoproteins, LDL-Low density lipoproteins, CHD-coronary heart disease
Citation
Deepthi S K, Naidu J N, Narayan Amar Raghu. Relationship between estrogen and lipid profile status in postmenopausal women. International Journal of Applied Biology and Pharmaceutical Technology. 2012 Jul-Sept; 3(3): 230-234.