E-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment.

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dc.contributor.authorArun, Ramya
dc.contributor.authorHemalatha, R
dc.contributor.authorArun, K V
dc.contributor.authorKumar, T S S
dc.date.accessioned2012-07-26T10:41:04Z
dc.date.available2012-07-26T10:41:04Z
dc.date.issued2010-07
dc.description.abstractBackground: Epithelial integrity is important for maintenance of periodontal health. It is not fully known if non-surgical periodontal therapy is capable of recreating the epithelial barrier in its functional state. Patients and Methods: Sixty-five patients (31 males and 34 females) were included in the study. They were divided into group A (healthy gingiva 16 patients), group B (gingivitis 17 patients), group C (periodontitis 17 patients), and group D (post-treatment 15 patients). Gingival samples were collected and immunohistochemical study was done using E-cadherin and CD1a antibody. Statistical analysis was done using analysis of variance (ANOVA), followed by Tukey-Kramer multiple comparison test for CD1a and Tukey's highly significant difference (HSD) test for E-cadherin. Result: There was a statistically significant difference (P<0.001) in the expression of E-cadherin between healthy (1.846±0.555), gingivitis (1.100±0.994), and periodontitis group (0.700±0.483). Similarly, there was a statistically significant difference (P<0.001) in the expression of CD1a between healthy (75.70±3.09), gingivitis (42.53±3.09), and periodontitis group (29.07±3.08). However, the expression of E-cadherin (1.242±0.653) and CD1a in post-treatment samples (52.18±2.90) was lower with no statistically significant difference when compared to health. Discussion: The significant reduction in E-cadherin and CD1a levels in periodontal disease when compared to health could possibly be a result of invasion by the periodontopathogens and its subsequent sequel. Although, the post-treatment samples showed significant improvement when compared to disease, the reduction in E-cadherin and CD1a levels when compared to gingival health suggests that the epithelial barrier was not yet fully established in its functional state.en_US
dc.identifier.citationArun Ramya, Hemalatha R, Arun K V, Kumar T S S. E-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment. Indian Journal of Dental Research. 2010 Jul-Sept; 21(3): 396-401.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139889
dc.language.isoenen_US
dc.source.urihttps://www.ijdr.in/article.asp?issn=0970-9290;year=2010;volume=21;issue=3;spage=396;epage=401;aulast=Arunen_US
dc.subjectCD1aen_US
dc.subjectdendritic cellsen_US
dc.subjectE-cadherinen_US
dc.subjectgingival epitheliumen_US
dc.subjectlangerhans cellsen_US
dc.subject.meshAdult
dc.subject.meshAntigens, CD1 --analysis
dc.subject.meshCadherins --analysis
dc.subject.meshCytoplasm --immunology
dc.subject.meshEpithelium --immunology
dc.subject.meshEpithelium --pathology
dc.subject.meshFemale
dc.subject.meshGingiva --immunology
dc.subject.meshGingiva --pathology
dc.subject.meshGingival Hemorrhage --immunology
dc.subject.meshGingival Hemorrhage --pathology
dc.subject.meshGingival Hemorrhage --therapy
dc.subject.meshGingivitis --immunology
dc.subject.meshGingivitis--pathology
dc.subject.meshGingivitis --therapy
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPeriodontal Attachment Loss --immunology
dc.subject.meshPeriodontal Attachment Loss --pathology
dc.subject.meshPeriodontal Attachment Loss --therapy
dc.subject.meshPeriodontal Pocket --immunology
dc.subject.meshPeriodontal Pocket --pathology
dc.subject.meshPeriodontal Pocket --therapy
dc.subject.meshPeriodontitis --immunology
dc.subject.meshPeriodontitis --pathology
dc.subject.meshPeriodontitis --therapy
dc.subject.meshYoung Adult
dc.titleE-cadherin and CD1a expression in gingival epithelium in periodontal health, disease and post-treatment.en_US
dc.typeArticleen_US
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