Antihypertensive drug prescription patterns and their impact on blood pressure outcomes in a tertiary care teaching hospital

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dc.contributor.authorKedare, R. K.en_US
dc.contributor.authorPujari, A. J.en_US
dc.contributor.authorHivale, N.en_US
dc.contributor.authorKharat, R.en_US
dc.date.accessioned2024-09-24T06:14:00Z
dc.date.available2024-09-24T06:14:00Z
dc.date.issued2024-08
dc.description.abstractBackground: The guidelines from the Joint National Committee (JNC-8) emphasize the importance of rapid blood pressure (BP) control to reduce morbidity and mortality. The success of hypertension treatment depends on various factors, with irrational prescription being strongly linked to poor BP control. This study aimed to evaluate the patterns of antihypertensive drug prescriptions among patients in a tertiary care teaching hospital. Methods: A hospital-based observational study was conducted in 2018, including all hypertensive patients on medication. Their prescription patterns were analyzed. Results: The study analyzed prescriptions from 240 hypertensive patients. The mean ages for male and female patients were 56.68±15.32 and 62.29±12.65 years, respectively. Physicians commonly prescribed monotherapy (34.60%) followed by two-drug (18.40%), three-drug (11.80%), and four-drug combinations (3.00%). The most frequent two-drug combination was ACE inhibitors + diuretics (4.40%), followed by angiotensin receptor blockers (ARBs) + diuretics (3.60%) and calcium channel blockers (CCBs) + ACE inhibitors (2.60%). Adherence to JNC 8 guidelines was 19.3% for pre-hypertension, 88.70% for stage 1 hypertension, and 73.29% for stage 2 hypertension. Conclusions: Monotherapies were the most commonly prescribed regimens. Twice-daily dosing and monthly appointments were associated with lower incidences of uncontrolled BP. However, complete adherence to standard guidelines was not observed in all cases, especially in patients with comorbid conditions.en_US
dc.identifier.affiliationsDepartment of Pharmacology, BJ Government Medical College, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Forensic Medicine and Toxicology, MIMER Medical College, Talegaon, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Bharatratna Atalbihari Vajpayee Medical College, Pune, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Forensic Medicine and Toxicology, Birsa Munda Government Medical College, Shahdol, Madhya Pradesh, Indiaen_US
dc.identifier.citationKedare R. K., Pujari A. J., Hivale N., Kharat R.. Antihypertensive drug prescription patterns and their impact on blood pressure outcomes in a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology. 2024 Jul; 13(4): 502-505en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/226766
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume13en_US
dc.source.urihttps://doi.org/10.18203/2319-2003.ijbcp20241650en_US
dc.subjectACE inhibitorsen_US
dc.subjectAntihypertensive drugsen_US
dc.subjectARBsen_US
dc.subjectCCBsen_US
dc.subjectDiureticsen_US
dc.subjectJNC-8 guidelinesen_US
dc.subjectPrescription patternsen_US
dc.titleAntihypertensive drug prescription patterns and their impact on blood pressure outcomes in a tertiary care teaching hospitalen_US
dc.typeJournal Articleen_US
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