ROLE OF CYTOKINE STORM IN COVID-19 SEVERITY AND ITS TREATMENT MANAGEMENT
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Date
2024-07
Journal Title
Journal ISSN
Volume Title
Publisher
Era's Lucknow Medical College & Hospital, Lucknow in association with American University of Barbados (AUB)
Abstract
The human body has defense systems called the innate and adaptive immune systems. These systems include cells that produce substances called cytokines, like interleukins and interferons, to help the body respond to infections and other challenges. Normally, there's a mild stability among the body's inflammatory and anti-inflammatory responses, regulated by complex mechanisms. When this balance is disrupted, it can trigger a cascade of reactions leading to a massive release of cytokines. This can cause a self-amplifying cycle, leading to severe damage, organ failure, or even death. Disturbances can be triggered not only by infections but also by genetic conditions or certain medical treatments that affect the immune system. Understanding and treating these situations are challenging because of the intricate interactions within the immune systems. There's still much to learn, and effective treatments are limited at the moment.
Description
Keywords
Cytokine storm, COVID-19, IL-6, IL-1.
Citation
Verma Shrikant, Verma Sushma, Afreen Sheeba, Abbas Mohammad, Mahdi Farzana . ROLE OF CYTOKINE STORM IN COVID-19 SEVERITY AND ITS TREATMENT MANAGEMENT . Era's Journal of Medical Research. 2024 Jul; 11(1): 105-112