Multiple Resistance in Clinical Isolates of Escherichia coli and Plasmid-mediated Quinolone Resistance Genes

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dc.contributor.authorAnayo, U. U.en_US
dc.contributor.authorOkechukwu, N. E.en_US
dc.contributor.authorNgozi, O. F.en_US
dc.contributor.authorAisida, S. O.en_US
dc.contributor.authorAnyachukwu, C. C.en_US
dc.date.accessioned2023-07-14T08:03:58Z
dc.date.available2023-07-14T08:03:58Z
dc.date.issued2023-02
dc.description.abstractQuinolone antibiotics have been commonly used to treat cases of multiple antibiotic resistance. Unfortunately, quinolone antibiotics have so much been resisted by infectious bacterial agents. This study aimed to evaluate the susceptibility of some clinical isolates of E. coli to some commonly used quinolone antibiotics and the determination of the plasmid-encoded quinolone resistance genes. Our results showed the plasmid quinolone-resistance genes in the following prevalence: qnr genes: qnr S (71.4 %); qnr B (15.4 %); qnr S and B (12.1 %); aac (6) lb-cr (4 %); Efflux genes: oqxA (7.7 %); oqxB (25.3 %); qepA (12.1 %); oqxA and oqxB (5.5 %). We conclude that there is a high frequency of Plasmid-mediated quinolone resistance genes in Escherichia coli isolates from clinical samples in South-Eastern Nigeria. These could be responsible for the high incidence of quinolone resistance reported in Enugu. There is a need for whole-genome sequencing to map out all resistance genes.en_US
dc.identifier.affiliationsDepartment of Medical Laboratory Science, University of Nigeria, Enugu Campus, Enugu, Nigeriaen_US
dc.identifier.affiliationsSafety Molecular Pathology Laboratory, Molecular Pathology Institute, Enugu State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Physics and Astronomy, University of Nigeria, Nsukka 41000, Nigeriaen_US
dc.identifier.affiliationsDepartment of Medical rehabilitation, University of Nigeria, Enugu Campus, Enugu, Nigeriaen_US
dc.identifier.citationAnayo U. U., Okechukwu N. E., Ngozi O. F., Aisida S. O., Anyachukwu C. C. . Multiple Resistance in Clinical Isolates of Escherichia coli and Plasmid-mediated Quinolone Resistance Genes. Annual Research & Review in Biology. 2023 Feb; 38(2): 1-11en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219417
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume38en_US
dc.source.urihttps://doi.org/10.9734/arrb/2023/v38i230568en_US
dc.subjectEscherichia colien_US
dc.subjectquinolone antibioticsen_US
dc.subjectplasmiden_US
dc.subjectantibioticsen_US
dc.subjectquinolone genesen_US
dc.titleMultiple Resistance in Clinical Isolates of Escherichia coli and Plasmid-mediated Quinolone Resistance Genesen_US
dc.typeJournal Articleen_US
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