A clinicopathological study of multidrug therapy in borderline tuberculoid leprosy.
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1994-10-01
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Abstract
A study was undertaken to evaluate the efficacy of multidrug therapy as per WHO recommendation in 50 fresh cases (46 males and 4 females) suffering from borderline tuberculoid leprosy. All were given multidrug therapy consisting of rifampicin 600 mg once a month and dapsone 100 mg daily for 6 months. At the end of 6 months all were evaluated clinically and histopathological examinations of the lesions were studied. The lesions were still active in 60% of patients clinically; 32% cases receiving multidrug therapy had shown marked improvement. Histologically lymphocytic infiltration in skin still persisted in all the slides examined and nerve infiltration was still present in 68% of cases at the end of 6 months after receiving multidrug therapy. The study shows that treatment with multidrug regimen for 6 months may not be sufficient to treat borderline tuberculoid leprosy cases.
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Kar PK, Arora PN, Ramasastry CV, Dhaka RS. A clinicopathological study of multidrug therapy in borderline tuberculoid leprosy. Journal of the Indian Medical Association. 1994 Oct; 92(10): 336-7