Simultaneous UV-Spectrophotometric estimation of Diclofenac and Tolperisone Hydrochloride in Tablet Dosage Form.

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dc.contributor.authorMahaparale, S P
dc.contributor.authorShinde, S S
dc.contributor.authorNirmal, P N
dc.date.accessioned2013-09-16T06:15:08Z
dc.date.available2013-09-16T06:15:08Z
dc.date.issued2013-08
dc.description.abstractDiclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Tolperisone hydrochloride is a piperidine derivative, is a centrally-acting muscle relaxant. Two simple, accurate and economic methods; Q analysis and first order derivative method have been described for the simultaneous spectrophotometric estimation of Diclofenac sodium and Tolperisone hydrochloride in tablet dosage form. Absorption maxima of Diclofenac sodium and Tolperisone hydrochloride in distilled water were found to be 275.0 nm and 260.0 nm respectively. Beer’s law was obeyed in the concentration range 5-50 μg/ml for Diclofenac and 5-60 μg/ml for Tolperisone hydrochloride. In Q analysis method, absorbances were measured at the selected wavelengths, 237.0 nm (isoabsorptive point) and 260.0 nm (λmax of Tolperisone). In first order derivative method, zero crossing point of Diclofenac sodium and Tolperisone hydrochloride were selected at 275.0 nm and 260.0 nm respectively. The analysis of binary pharmaceutical formulation was carried by both methods. Results of two methods were validated statistically by recovery studies and were found to be satisfactory.en_US
dc.identifier.citationMahaparale S P, Shinde S S, Nirmal P N. Simultaneous UV-Spectrophotometric estimation of Diclofenac and Tolperisone Hydrochloride in Tablet Dosage Form. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Aug-Sept; 2(5): 574-579.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/148284
dc.language.isoenen_US
dc.source.urihttps://www.ijrdpl.com/docs/currentissue%20aug%20sept%202013/6.pdfen_US
dc.subjectDiclofenac sodium (DIC)en_US
dc.subjectTolperisone hydrochloride (TOL)en_US
dc.subjectUltraviolet spectrophotometryen_US
dc.subjectQ - Analysis method and First order methoden_US
dc.titleSimultaneous UV-Spectrophotometric estimation of Diclofenac and Tolperisone Hydrochloride in Tablet Dosage Form.en_US
dc.typeArticleen_US
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