From sequence to consequence: Deciphering the complex cis-regulatory landscape

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dc.contributor.authorDSILVA, GREG JUDEen_US
dc.contributor.authorGALANDE, SANJEEVen_US
dc.date.accessioned2024-11-30T11:24:41Z
dc.date.available2024-11-30T11:24:41Z
dc.date.issued2024-03
dc.description.abstractCell type-specific expression of genes plays a pivotal role in the development and evolution of multicellular organisms over millions of years. The majority of regulatory control resides within the non-coding regions of the genome, referred to as ‘dark matter’, which contains cis-regulatory modules. These cis-regulatory modules function collectively and can impact gene expression even when located far from the target gene, exhibiting context-specific behaviour. Consequently, the cis-regulatory code governing gene expression patterns is intricate, in contrast to the universally understood genetic code. This overview centres on the current knowledge regarding cis-regulatory elements, primarily enhancers and their role in governing the spatiotemporal gene expression patterns, and how they have evolved and adapted across different species.en_US
dc.identifier.affiliationsLaboratory of Chromatin Biology and Epigenetics, Department of Biology, Indian Institute of Science Education and Research, Pune 411 008, Indiaen_US
dc.identifier.affiliationsLaboratory of Chromatin Biology and Epigenetics, Department of Biology, Indian Institute of Science Education and Research, Pune 411 008, India; Centre of Excellence in Epigenetics, Department of Life Sciences, Shiv Nadar Institution of Eminence, Gautam Buddha Nagar 201 324, Indiaen_US
dc.identifier.citationDSILVA GREG JUDE, GALANDE SANJEEV. From sequence to consequence: Deciphering the complex cis-regulatory landscape. Journal of Biosciences. 2024 Mar; 49: 1-11en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237966
dc.languageenen_US
dc.publisherThe Indian Academy of Sciencesen_US
dc.relation.volume49en_US
dc.source.urihttps://doi.org/10.1007/s12038-024-00431-0en_US
dc.subjectCis-regulatory elementsen_US
dc.subjectenhancersen_US
dc.subjectrewiringen_US
dc.subjectspatiotemporal patterningen_US
dc.subjecttranscription factorsen_US
dc.subjectgene expressionen_US
dc.titleFrom sequence to consequence: Deciphering the complex cis-regulatory landscapeen_US
dc.typeJournal Articleen_US
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