From sequence to consequence: Deciphering the complex cis-regulatory landscape
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Date
2024-03
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The Indian Academy of Sciences
Abstract
Cell type-specific expression of genes plays a pivotal role in the development and evolution of multicellular organisms over millions of years. The majority of regulatory control resides within the non-coding regions of the genome, referred to as ‘dark matter’, which contains cis-regulatory modules. These cis-regulatory modules function collectively and can impact gene expression even when located far from the target gene, exhibiting context-specific behaviour. Consequently, the cis-regulatory code governing gene expression patterns is intricate, in contrast to the universally understood genetic code. This overview centres on the current knowledge regarding cis-regulatory elements, primarily enhancers and their role in governing the spatiotemporal gene expression patterns, and how they have evolved and adapted across different species.
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Keywords
Cis-regulatory elements, enhancers, rewiring, spatiotemporal patterning, transcription factors, gene expression
Citation
DSILVA GREG JUDE, GALANDE SANJEEV. From sequence to consequence: Deciphering the complex cis-regulatory landscape. Journal of Biosciences. 2024 Mar; 49: 1-11