Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract.

Simple item page
dc.contributor.authorDhuley, J Nen_US
dc.date.accessioned2003-02-12en_US
dc.date.accessioned2009-05-27T04:14:38Z
dc.date.available2003-02-12en_US
dc.date.available2009-05-27T04:14:38Z
dc.date.issued2003-02-12en_US
dc.description.abstractThe Study was designed to verify the gastroprotective and antidiarrhoeal effects of unripe fruit extract of Aegle marmelos Corr. The gastroprotective function of this extract was evaluated in rats against gastric mucosal damage induced by hypothermic restraint stress, absolute ethanol, and indomethacin, whereas the antidiarrhoeal activity was investigated by studying the influence on gastrointestinal transit as measured by a charcoal marker and on castor oil-induced accumulation of intestinal fluid in mice and also on contractile responses evoked by acetylcholine, histamine, serotonin, and barium chloride in isolated guinea-pig ileum, the results demonstrated that pretreatment of animals with unripe fruit extract (50 and 100 mg/kg, i.p.) produces a significant inhibition of gastric lesion induced by ethanol but not those induced by restraint stress or indomethacin and suggest a probable involvement of a prostaglandin-independent mechanism of gastroprotection. At similar doses, both the intestinal transit as well as the accumulation of intestinal fluids induced by castor oil in mice were significantly inhibited by raw fruit extract. Furthermore, the extract antagonized the contractile responses evoked by different agonists on guinea-pig ileum in vitro and its inhibitory potential for the drugs are in the order of acetylcholine > histamine > serotonin > barium chloride. Taken together, these results point out a possible antidiarrhoeal effect of unripe fruit extract of A. marmelos Corr., since inhibition of intestinal motility and secretion can control clinical diarrhoea.en_US
dc.description.affiliationPharmacology & Toxicology section, Research Centre, Hindustan Antibiotics Limited, Pimpri, Pune 411 018, India.en_US
dc.identifier.citationDhuley JN. Investigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract. Hindustan Antibiotics Bulletin. 2003 Feb-2004 Nov; 45-46(1-4): 41-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/2321
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidalen_US
dc.subject.meshAnti-Ulcer Agents --isolation & purificationen_US
dc.subject.meshAntidiarrheals --isolation & purificationen_US
dc.subject.meshCentral Nervous System Depressantsen_US
dc.subject.meshEthanolen_US
dc.subject.meshFruit --chemistryen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIndomethacinen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMuscle Contraction --drug effectsen_US
dc.subject.meshMuscle, Smooth --drug effectsen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRutaceae --chemistryen_US
dc.subject.meshStomach Ulcer --chemically induceden_US
dc.subject.meshStress, Psychological --complicationsen_US
dc.titleInvestigation on the gastroprotective and antidiarrhoeal properties of Aegle marmelos unripe fruit extract.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Hindustan Antibiotics Bulletin