Pharmacological actions of tentacle extract of the jellyfish, Acromitus rabanchatu, occurring in the Bay of Bengal.

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dc.contributor.authorGhosh, T Ken_US
dc.contributor.authorGomes, Aen_US
dc.contributor.authorChaudhuri, A Ken_US
dc.date.accessioned2009-05-28T11:10:28Z
dc.date.available2009-05-28T11:10:28Z
dc.date.issued1990-01-01en_US
dc.description.abstractTentacle extract of A.rabanchatu, produced a fall of blood pressure in cat, rat and guinea pig. Hypotension produced in cat remained unantagonized by blockers of acetylcholine, histamine and 5-HT. On isolated guinea pig heart, the extract significantly reduced the rate and amplitude of contraction leading to irreversible cardiac arrest. In cats and rats, the respiratory rate and amplitude was decreased significantly and resulted in temporary apnoea. The extract also produced vasoconstriction in perfused rat hindquarter preparation and increased cutaneous capillary permeability. The extract produced contraction in several isolated smooth muscle preparations. Contraction on guinea pig ileum was partly antagonized by atropine and cyproheptadine. On isolated rat phrenic nerve diaphragm and chick biventer cervicis, the extract produced irreversible blockade of the electrical stimulation-induced twitch responses. Haemolytic and myonecrotic activity was exhibited by the extract. LD50 was found to be 7.7 mg/kg (iv, mice).en_US
dc.description.affiliationDepartment of Pharmacy, Jadavpur University, Calcutta, India.en_US
dc.identifier.citationGhosh TK, Gomes A, Chaudhuri AK. Pharmacological actions of tentacle extract of the jellyfish, Acromitus rabanchatu, occurring in the Bay of Bengal. Indian Journal of Experimental Biology. 1990 Jan; 28(1): 39-42en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56343
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCapillary Permeabilityen_US
dc.subject.meshCatsen_US
dc.subject.meshCnidarian Venoms --pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIndiaen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMyocardial Contractionen_US
dc.subject.meshRatsen_US
dc.subject.meshRespirationen_US
dc.titlePharmacological actions of tentacle extract of the jellyfish, Acromitus rabanchatu, occurring in the Bay of Bengal.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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