Tranexamic acid in paediatric cardiac surgery.

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dc.contributor.authorChauhan, Sandeepen_US
dc.contributor.authorBisoi, Akshayen_US
dc.contributor.authorModi, Rakeshen_US
dc.contributor.authorGharde, Paragen_US
dc.contributor.authorRajesh, M Ren_US
dc.date.accessioned2003-08-19en_US
dc.date.accessioned2009-05-27T07:21:16Z
dc.date.available2003-08-19en_US
dc.date.available2009-05-27T07:21:16Z
dc.date.issued2003-08-19en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Antifibrinolytic agents are used commonly in adult cardiac surgery to reduce postoperative blood loss. Paucity of literature on the use of a newer antifibrinolytic agent tranexamic acid (TA) in children undergoing cardiac surgery promoted us to conduct this study in children with cyanotic heart disease. METHODS: One hundred and twenty consecutive children with cyanotic heart disease were randomised into two groups. Control (group A) (n=24) given no drug while the study (group B, n=96) group was given tranexamic acid 10 mg/kg each after anaesthetic induction, on bypass and after protamine at the end of bypass. Postoperatively, total mediastinal chest tube drainage and blood and blood product usage at 24 h were recorded. Tests of coagulation including activated clotting time, fibrinogen, fibrin degradation products and platelet count were performed at 6 h postoperatively. RESULTS: The two groups were comparable in terms of demographic characteristics such as age, sex, weight, operations performed, and preoperative haematocrit. Postoperatively, group B, had a significantly (P<0.05) lower blood loss, blood and blood product usage, re-exploration rate compared to the control group. There was preservation of fibrinogen and lower levels of fibrin degradation products in group B. INTERPRETATION & CONCLUSION: Tranexamine acid was highly effective in reducing post-operative blood loss, blood and blood product usage in children with congenital cyanotic heart disease undergoing corrective surgery.en_US
dc.description.affiliationDepartment of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences Ansari Nagar, New Delhi, India. sdeep61@yahoo.comen_US
dc.identifier.citationChauhan S, Bisoi A, Modi R, Gharde P, Rajesh MR. Tranexamic acid in paediatric cardiac surgery. Indian Journal of Medical Research. 2003 Aug; 118(): 86-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20362
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntifibrinolytic Agents --therapeutic useen_US
dc.subject.meshCardiac Surgical Proceduresen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshPediatricsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTranexamic Acid --therapeutic useen_US
dc.titleTranexamic acid in paediatric cardiac surgery.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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