Effect of simvastatin on fracture healing--an experimental study.

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dc.contributor.authorSaraf, S Ken_US
dc.contributor.authorSingh, Ajiten_US
dc.contributor.authorGarbyal, R Sen_US
dc.contributor.authorSingh, Vakilen_US
dc.date.accessioned2009-05-28T13:58:27Z
dc.date.available2009-05-28T13:58:27Z
dc.date.issued2007-05-16en_US
dc.description.abstractLeft femur was osteotomized and fixed with K wire in 21 rabbits. One group was fed simvastatin (120 mg/kg body wt/day) orally, whereas another group without medication served as control. Both groups were assessed radiologically, morphologically, histologically and biomechanically at 4, 8 and 12 weeks. An analysis of various parameters of study showed that simvastatin treated group had improved bone healing at 4 and 8 weeks of follow up, however, the difference was not significant statistically at 12 weeks. So it is concluded that Simvastatin favourably hastened the process of fracture healing in the rabbits at earlier phases.en_US
dc.description.affiliationDepartment of Orthopaedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. sksaraf36@hotmail.comen_US
dc.identifier.citationSaraf SK, Singh A, Garbyal RS, Singh V. Effect of simvastatin on fracture healing--an experimental study. Indian Journal of Experimental Biology. 2007 May; 45(5): 444-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/60106
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/5526/1/IJEB%2045%285%29%20444-449.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Resorption --prevention & controlen_US
dc.subject.meshBony Callus --drug effectsen_US
dc.subject.meshFemur --injuriesen_US
dc.subject.meshFracture Healing --drug effectsen_US
dc.subject.meshFractures, Bone --drug therapyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSimvastatin --pharmacologyen_US
dc.subject.meshStress, Mechanicalen_US
dc.subject.meshTime Factorsen_US
dc.titleEffect of simvastatin on fracture healing--an experimental study.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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