Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

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dc.contributor.authorJuneja, Saurabhen_US
dc.contributor.authorAgarwal, Ruchien_US
dc.contributor.authorAgarwal, Deeptien_US
dc.contributor.authorRana, Parveenen_US
dc.contributor.authorSingh, Kulwanten_US
dc.contributor.authorKaur, Swaranen_US
dc.date.accessioned2020-09-24T07:10:58Z
dc.date.available2020-09-24T07:10:58Z
dc.date.issued2019-09
dc.description.abstractIntroduction: Breast carcinoma is the most common canceramong women in both developing and developed countries.It needs alarming attention because it causes high morbidityand mortality. There is a need to understand the initiationand progression of breast cancer on hormonal, cellular andmolecular basis which forms the platform for designing oftargeted therapy. This study was intended to find correlationbetween the expression of Estrogen receptor, Progesteronereceptor and Human Epidermal Growth Factor Receptor-2with histological grade in cases of carcinoma breast.Material and methods: This study was conducted in theDepartment of Pathology at Bhagat Phool Singh GovernmentMedical College for Women, Khanpur Kalan, Sonepat on 55histologically confirmed breast cancer cases.Results: The age of the patients ranged from 27 to 70 yearsand the mean age was 51.56 ± 11.39 years. Invasive ductalcarcinoma - no special type was the most common histologicaltype(92.72%). The most common histological grade observedwas grade II i.e. 61.82%. Lymph nodes involvement was seenin 55.32% of the cases. ER, PR and HER-2/neu positivitywas observed in 45.45%, 47.27% and 25.45% of the casesrespectively. ER and PR were found to correlate withhistological grade (p<0.05) while no correlation was observedbetween HER-2/neu and histological grade(p>0.05).Conclusion: Evaluation of ER, PR, and HER-2/neu statusshould be incorporated routinely as a part of histopathologyreports in all cases of breast carcinoma as they not onlyhelp in assessment of prognosis, but also help in decidingmanagement and improving overall survival.en_US
dc.identifier.affiliationsPG student 3rd year, Department of Pathology, BPS Government Medical College for Women, Khanpur Kalan, Sonepaten_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, BPS Government Medical College for Women, Khanpur Kalan, Sonepaten_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, BPS Government Medical College for Women, Khanpur Kalan, Sonepaten_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, BPS Government Medical College for Women Khanpur Kalan, Sonepaten_US
dc.identifier.affiliationsAssociate Professor, Department of Pathology, BPS Government Medical College for Women, Khanpur Kalan, Sonepaten_US
dc.identifier.affiliationsProfessor, Department of Pathology, BPS Government Medical College for Women, Khanpur Kalan, Sonepat, Indiaen_US
dc.identifier.citationJuneja Saurabh, Agarwal Ruchi, Agarwal Deepti, Rana Parveen, Singh Kulwant, Kaur Swaran. Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast . International Journal of Contemporary Medical Research . 2019 Sep; 6(9): i6-i11en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202588
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber9en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.9.26en_US
dc.subjectCarcinoma Breasten_US
dc.subjectEstrogen Receptoren_US
dc.subjectHistological Gradeen_US
dc.subjectHuman Epidermal Growth Factor Receptor-2en_US
dc.subjectProgesterone Receptoren_US
dc.titleCorrelation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breasten_US
dc.typeJournal Articleen_US
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