Lethality and Antioxidant Activity of some Sudanese Medicinal Plants’ Fixed Oils.
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Date
2014-05
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Abstract
The objective of the undergoing work is investigating antitumor therapy potential and
antioxidant capacity of Sudanese medicinal plants Helianthus annuus L. (Asteraceae),
Ricinus communis L. (Euphorbiaceae), Nigella sativa L. (Ranunculaceae), Sesamum
indicum L. (Pedaliaceae) and Balanites aegyptiaca (L.) Del (Zygophyllaceae) by studying
the plants seeds fixed oils for their cytotoxicity and antioxidant activity. This study was
conducted at the Sudan National Research Center, Medicinal & Aromatic Plants
Research Center, Khartoum, Sudan, in June-August, 2013. The five fixed oils cytotoxicity
was studied using Brine Shrimp Lethality and antioxidant activity by DPPH and Iron
Chelating Assays. Obtained results showed that Ricinus communis fixed oil has the
highest toxicity with LC50 1.7014, followed by Nigella sativa with LC50 606.2, when
analyzed by Finney Probit Analysis. Antioxidant activity results of the five fixed oils
measured using DPPH showed that Nigella sativa fixed oil showed high antioxidant
potential (85%), while Ricinus communis and Helianthus annuus fixed oils showed
moderate antioxidant activity (52%) and (51%) respectively. All of the fixed oils showed no activity when using Iron Chelating Assay. Results justify the plants use in folkloric
medicine although dosages should be monitored for its safe use. Studies directed towards
identification of bioactive compounds are recommended.
Description
Keywords
Medicinal plants, fixed oils, cytotoxicity, antioxidants
Citation
Abushama Muna F, Hilmi Yasmin I, AbdAlgadir Haidar M, Fadul Eltayeb, Khalid Hassan E. Lethality and Antioxidant Activity of some Sudanese Medicinal Plants’ Fixed Oils. European Journal of Medicinal Plants. 2014 May; 4(5): 563-570.