CDRI-85/287: studies on competition to estrogen binding sites in the immature rat uterus.

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dc.contributor.authorSreenivasulu, Sen_US
dc.contributor.authorDwivedi, Aen_US
dc.contributor.authorSingh, M Men_US
dc.contributor.authorSetty, B Sen_US
dc.contributor.authorKamboj, V Pen_US
dc.date.accessioned2009-05-28T12:16:07Z
dc.date.available2009-05-28T12:16:07Z
dc.date.issued1992-12-01en_US
dc.description.abstractAbility of compound CDRI-85/287, a new nonsteroidal antiestrogen with negligible inherent estrogenicity, to inhibit uptake of 3H-estradiol (3H-E2) by the immature rat uterus in vivo was investigated. Different doses of 85/287 were administered either intraperitoneally 30 min before 3H-E2 or orally 1 and 6 hr before 3H-E2. A dose dependent inhibition in 3H-E2 uptake was observed after administration of the compound by either route and was 69% at 50 micrograms/rat ip dose and 80% at 2.5 mg/kg po dose. In in vitro competitive binding assay, however, the compound showed poor affinity (RBA 0.42% of estradiol-17 beta) for cytosolic estrogen receptors. Considering the potent anti-estrogenic as well as anti-implantation efficacy of the compound, its action in vivo appears to be mediated via its active metabolite(s).en_US
dc.description.affiliationDivision of Endocrinology, Central Drug Research Institute, Lucknow, India.en_US
dc.identifier.citationSreenivasulu S, Dwivedi A, Singh MM, Setty BS, Kamboj VP. CDRI-85/287: studies on competition to estrogen binding sites in the immature rat uterus. Indian Journal of Experimental Biology. 1992 Dec; 30(12): 1115-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/57850
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBenzopyrans --pharmacologyen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshBinding, Competitiveen_US
dc.subject.meshCytosol --metabolismen_US
dc.subject.meshEstradiol --metabolismen_US
dc.subject.meshEstrogen Antagonists --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshKineticsen_US
dc.subject.meshPiperidines --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Estrogen --drug effectsen_US
dc.subject.meshUterus --drug effectsen_US
dc.titleCDRI-85/287: studies on competition to estrogen binding sites in the immature rat uterus.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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