Association of Polymorphisms in DAZL Gene with Male Infertility.

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dc.contributor.authorKhabour, Omar F
dc.contributor.authorAl-azzam, Akram M
dc.contributor.authorAlfaouri, Almuthana A
dc.contributor.authorZayed, Faheem
dc.contributor.authorSadiq, May F
dc.date.accessioned2015-08-31T08:14:44Z
dc.date.available2015-08-31T08:14:44Z
dc.date.issued2013-01
dc.description.abstractObjectives: To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males. Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Results: The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility. Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.en_US
dc.identifier.citationKhabour Omar F, Al-azzam Akram M, Alfaouri Almuthana A, Zayed Faheem, Sadiq May F. Association of Polymorphisms in DAZL Gene with Male Infertility. British Journal of Medicine and Medical Research. 2013 Jan-Mar; 3(1): 41-48.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/162783
dc.language.isoenen_US
dc.source.urihttps://sciencedomain.org/abstract/752en_US
dc.subjectDeleted in azoospermia-like geneen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjectJordanen_US
dc.subjectinfertilityen_US
dc.subjectmaleen_US
dc.titleAssociation of Polymorphisms in DAZL Gene with Male Infertility.en_US
dc.typeArticleen_US
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