Effects of bleomycin and Staphylococcus protein-A on lungs of mice.

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dc.contributor.authorSahu, A Pen_US
dc.contributor.authorLal, Ken_US
dc.date.accessioned2009-05-28T11:33:24Z
dc.date.available2009-05-28T11:33:24Z
dc.date.issued1995-10-01en_US
dc.description.abstractFibrosis of organs and tissues are major causes of morbidity and mortality in human. The currently available pharmacologically based treatments are unsatisfactory. As an experimental animal model antitumor antibiotic drug bleomycin (BLM) is widely used to produce lung fibrosis. The present study has been undertaken to investigate the possible role of a potent immunomodulator Staphylococcus protein-A (SpA) in the modulation of lung lesions caused by treatment of BLM. In mice BLM, 0.5 mg in 200 microliters of normal saline and SpA, 6 micrograms in 200 microliters of normal saline was administered singly or in combination twice a week for 4 weeks. The fibrotic lesions in the lungs were observed after 4 weeks of BLM treatment. After 4 weeks treatment of SpA, the hyperreactive changes in bronchi and bronchioles were observed. In the co-treatment group of BLM and SpA, the effects observed were in the form of enhanced lesions in the lung parenchyma. Moreover, the pleural lesions were also observed in co-treatment group (BLM + SpA). Opposite to the assumption, SpA being a potent immunomodulator was not able to reduce the lung lesions produced by BLM.en_US
dc.description.affiliationPreventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.en_US
dc.identifier.citationSahu AP, Lal K. Effects of bleomycin and Staphylococcus protein-A on lungs of mice. Indian Journal of Experimental Biology. 1995 Oct; 33(10): 734-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56879
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibiotics, Antineoplastic --toxicityen_US
dc.subject.meshBleomycin --toxicityen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPulmonary Fibrosis --chemically induceden_US
dc.subject.meshStaphylococcal Protein A --toxicityen_US
dc.titleEffects of bleomycin and Staphylococcus protein-A on lungs of mice.en_US
dc.typeJournal Articleen_US
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