Ageing, gerontogenes, and hormesis.

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dc.contributor.authorRattan, S Ien_US
dc.date.accessioned2009-05-28T16:30:52Z
dc.date.available2009-05-28T16:30:52Z
dc.date.issued2000-01-10en_US
dc.description67 references.en_US
dc.description.abstractEvolutionary theories of ageing and longevity argue against the existence of specific genes that cause ageing. However, genes whose altered activity influences ageing and longevity, may be termed gerontogenes. Several putative gerontogenes have been identified in various ageing systems, including the Drosophila, budding yeast, nematodes and cells in culture. Since ageing is characterized by a progressive failure of maintenance and repair, it is reasoned that genes involved in homeodynamic repair pathways are the most likely candidate gerontogenes. A promising approach for the identification of critical gerontogenic processes is hormesis-like positive effects of stress. Stimulation of various repair pathways by mild stress has significant effects on delaying the onset of various age-associated alterations in cells, tissues and organisms.en_US
dc.description.affiliationDanish Centre for Molecular Gerontology, Laboratory of Cellular Ageing, Department of Molecular and Structural Biology, University of Aarhus, Gustav Wieds Vej, DK-8000 Aarhus-C, Denmark. rattan@imsb.au.dken_US
dc.identifier.citationRattan SI. Ageing, gerontogenes, and hormesis. Indian Journal of Experimental Biology. 2000 Jan; 38(1): 1-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63328
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAging --geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCaenorhabditis elegans --geneticsen_US
dc.subject.meshCell Aging --physiologyen_US
dc.subject.meshDrosophila melanogaster --geneticsen_US
dc.subject.meshEvolutionen_US
dc.subject.meshForecastingen_US
dc.subject.meshGene Expression Regulation --geneticsen_US
dc.subject.meshGenesen_US
dc.subject.meshGenes, Fungalen_US
dc.subject.meshGenes, Helminthen_US
dc.subject.meshGenes, Insecten_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage (Genetics)en_US
dc.subject.meshLongevity --geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshSaccharomyces cerevisiae --geneticsen_US
dc.subject.meshStress, Physiological --geneticsen_US
dc.titleAgeing, gerontogenes, and hormesis.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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