Synthesis and Development of BACE 1 Inhibitor for Alzheimer’s Diseases from Medicinal Plants

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dc.contributor.authorAbdul, Bakrudeen Ali Ahmeden_US
dc.contributor.authorVidhyavathi, R.en_US
dc.contributor.authorMagesh, J.en_US
dc.contributor.authorVijayakumar, M.en_US
dc.contributor.authorMustafa, Muneeb M.en_US
dc.contributor.authorMarikar, Faiz M. M. T.en_US
dc.date.accessioned2019-12-06T09:18:29Z
dc.date.available2019-12-06T09:18:29Z
dc.date.issued2018-08
dc.description.abstractMedicinal plants have shown great promise in treating Alzheimer’s disease (AD), which significantly contributes to the production of pharmaceutical and cosmetic molecules with biologically efficient moieties. Plants derived bioactive compounds have been isolated from the medicinal plants and are used in brain diseases. Accountable for brain diseases. Plant extracts have undesirable effects such as acute or chronic toxicity; this could be involved in the delay or discouraging the adoption to the brain cells for proper and effective treatment. β-secretase is the primary protease in the process of producing Amyloid β (Aβ), which is an amyloid precursor protein in brain cells. This review is focused on the numerous different bioactive compounds present in medicinal plants such as Flavonoids, Phenyl propanoids, Prenylated flavones, Naphthoquinone, Resveratrol, Phlorotannins and Glycoside derivatives. Even though medicinal plants and their functional derivatives were reported to be good source of alternative medicines for long sought diseases like AD; but clinical trials on human are yet to be beyond the preliminary stages. The useful applications of these compounds, as bio-markers are also being explored, to further enrich control of Alzheimer’s.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Centre for Research and Development (CRD), PRIST Deemed University, Thanjavur-613 403, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Centre for Research and Development (CRD), PRIST Deemed University, Thanjavur-613 403, India.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Centre for Research and Development (CRD), PRIST Deemed University, Thanjavur-613 403, India.en_US
dc.identifier.affiliationsDairy Science Division, National Institute of Animal Science, Rural Development Administration, Cheonan-si, 31000, Chungcheongnam-do, Republic of Korea.en_US
dc.identifier.affiliationsFaculty of Science, Institute of Biological Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia.en_US
dc.identifier.affiliationsGeneral Sir John Kotelawala Defence University, Kandawala Estate, Ratmalana, 10350, Sri Lanka.en_US
dc.identifier.citationAbdul Bakrudeen Ali Ahmed, Vidhyavathi R., Magesh J., Vijayakumar M., Mustafa Muneeb M., Marikar Faiz M. M. T.. Synthesis and Development of BACE 1 Inhibitor for Alzheimer’s Diseases from Medicinal Plants. Annual Research & Review in Biology. 2018 Aug; 28(3): 1-18en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187912
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume28en_US
dc.source.urihttps://doi.org/10.9734/ARRB/2018/40571en_US
dc.subjectMedicinal planten_US
dc.subjectnatural productsen_US
dc.subjectessential oilen_US
dc.subjectclinical trialsen_US
dc.subjectBACE 1 inhibitorsen_US
dc.subjectAlzheimer’s diseaseen_US
dc.titleSynthesis and Development of BACE 1 Inhibitor for Alzheimer’s Diseases from Medicinal Plantsen_US
dc.typeJournal Articleen_US
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