INSTAPRESERVETM: AN ALTERNATIVE FIXATIVE TO FORMALIN AND SUITABLE FOR HISTOPATHOLOGY

Simple item page
dc.contributor.authorVANGALA, RKen_US
dc.contributor.authorVANGALA, ABen_US
dc.contributor.authorKANUKOLLU, Sen_US
dc.contributor.authorMS., Pen_US
dc.contributor.authorREDDY, C. Nen_US
dc.contributor.authorS., Aen_US
dc.contributor.authorP., Jen_US
dc.contributor.authorNAIR, Jen_US
dc.contributor.authorNAIR, PNen_US
dc.contributor.authorMURUGAIAN, EE.en_US
dc.date.accessioned2025-05-12T07:20:51Z
dc.date.available2025-05-12T07:20:51Z
dc.date.issued2024-08
dc.description.abstractObjective: To evaluate the efficacy of InstaPRESERVETM for replacing formalin in histopathology. Methods: Tissue from seven organs from a pig was fixed with InstaPRESERVETM and formalin for 6 h, 12 h, and 24 h. Microtome sections at three time points were stained with hematoxylin and eosin and evaluated for intactness, and nuclear and cytoplasmic staining. Scoring was done based on their quality. Results: Gross findings were well appreciated for the tissue specimens fixed with InstaPRESERVETM compared to formalin. Unlike formalin, discoloration was lesser and the rigidity was mild to firm with InstaPRESERVETM fixation. The penetration rate of InstaPRESERVETM was equivalent to formalin and the morphology and intactness were well preserved. The nuclear and cytoplasmic H and E staining intensity of InstaPRESERVETM fixed tissues was comparable to formalin fixation. Conclusion: The promising results from InstaPRESERVETM fixed tissues of pig organs are encouraging. This preliminary study is positive on replacing formalin in routine histopathology thus preventing the pathology laboratory personnel from occupational hazards. Further studies with human specimens are required to escalate InstaPRESERVETM to medical histopathology.en_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsSpectrum Diagnostics, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.affiliationsNeuome Technologies Private Limited, Electronic City, Bangalore, Indiaen_US
dc.identifier.citationVANGALA RK, VANGALA AB, KANUKOLLU S, MS. P, REDDY C. N, S. A, P. J, NAIR J, NAIR PN, MURUGAIAN EE.. INSTAPRESERVETM: AN ALTERNATIVE FIXATIVE TO FORMALIN AND SUITABLE FOR HISTOPATHOLOGY . International Journal of Pharmacy and Pharmaceutical Sciences . 2024 Aug; 16(8): 17-20en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246459
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber8en_US
dc.relation.volume16en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2024v16i8.51552en_US
dc.subjectHistopathologyen_US
dc.subjectFormalinen_US
dc.subjectFixativeen_US
dc.subjectFormalin alternativeen_US
dc.titleINSTAPRESERVETM: AN ALTERNATIVE FIXATIVE TO FORMALIN AND SUITABLE FOR HISTOPATHOLOGYen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijpps2024v16n8p17.pdf
Size:
869.68 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmacy and Pharmaceutical Sciences