Development of natural gum based glipizide mucoadhesive microsphere.
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Date
2014-01
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Abstract
The objective of this study was to develop glipizide microsphere with natural gums. Guar gum and xanthan gum
were used separately in different ratios as natural polymers. The microspheres were prepared by orifice ionic
gelation method and they were characterized by scanning electron microscopy and particle size analysis. Among
six formulations, microspheres of four formulations (F1-F4) were discrete, sphrerical and free flowing. There was
an inverse relationship found between the amount of gum and surface smoothness in case of guar gum-containing
microspheres while a forward relationship was found between amount of gum and surface smoothness in case of
the microspheres containing xanthan gum. The size of the particles increased with increasing amounts of gum. It
can be concluded that guar gum and natural gum at a ratio of 1:0.25 and 1:0.5 can be ideal for formulating natural
gum based glipizide mucoadhesive microsphere.
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Keywords
Glipizide, mucoadhesive microsphere, guar gum, xanthan gum, ionic gelation method
Citation
Mamun Md Abdur Rouf Al, Bagchi Monisha, Amin Md Lutful, Sutradhar Kumar Bishwajit, Huda Naz Hasan. Development of natural gum based glipizide mucoadhesive microsphere. Journal of Applied Pharmaceutical Science. 2014 Jan; 4(1): 66-69.